Feature Listing

[+]  | YAL069W~Dubious | WN66_00001 | protein_coding | Gene | gene0 | SGD:S000002143 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | | WN66_00001

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[+]  | YAL068W-A~Dubious | WN66_00002 | protein_coding | Gene | gene1 | SGD:S000028594 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching | | | WN66_00002

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[+]  | YAL068C~PAU8~Verified | WN66_00003 | protein_coding | Gene | gene2 | SGD:S000002142 | Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions | PAU8 | | WN66_00003

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[+]  | YAL067W-A~Uncharacterized | WN66_00004 | pseudogene | Gene | gene3 | SGD:S000028593 | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching | | true | WN66_00004

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[+]  | hYIR044C | WN66_00005 | pseudogene | Gene | gene4 | | | | true | WN66_00005

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[+]  | YAL067C~SEO1~Verified | WN66_00006 | protein_coding | Gene | gene5 | SGD:S000000062 | Putative permease; member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide | SEO1 | | WN66_00006

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[+]  | YAL066W~Dubious | WN66_00007 | protein_coding | Gene | gene6 | SGD:S000000061 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | | WN66_00007

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[+]  FLO59 | YAL063C | FLO59 | protein_coding | Gene | gene7 | | | | | WN66_00008

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[+]  | YAL064W-B~Uncharacterized | WN66_00009 | protein_coding | Gene | gene8 | SGD:S000002141 | Fungal-specific protein of unknown function | | | WN66_00009

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[+]  | YAL062W~GDH3,FUN51~Verified | WN66_00010 | protein_coding | Gene | gene9 | SGD:S000000058 | NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication | GDH3 | | WN66_00010

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[+]  | YAL061W~BDH2~Uncharacterized | WN66_00011 | protein_coding | Gene | gene10 | SGD:S000000057 | Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3 | BDH2 | | WN66_00011

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[+]  | YAL060W~BDH1,BDH~Verified | WN66_00012 | protein_coding | Gene | gene11 | SGD:S000000056 | NAD-dependent (R,R)-butanediol dehydrogenase; catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source | BDH1 | | WN66_00012

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[+]  | YAL059C-A~Dubious | WN66_00013 | protein_coding | Gene | gene12 | SGD:S000028734 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene ECM1/YAL059W | | | WN66_00013

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[+]  | YAL059W~ECM1~Verified | WN66_00014 | pseudogene | Gene | gene13 | SGD:S000000055 | Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm | ECM1 | true | WN66_00014

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[+]  | YAL058W~CNE1,FUN48~Verified | WN66_00015 | protein_coding | Gene | gene14 | SGD:S000000054 | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast | CNE1 | | WN66_00015

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[+]  | YAL056C-A~YAL058C-A~Dubious | WN66_00016 | protein_coding | Gene | gene15 | SGD:S000002139 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | | WN66_00016

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[+]  | YAL056W~GPB2,KRH1~Verified | WN66_00017 | protein_coding | Gene | gene16 | SGD:S000000052 | Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication | GPB2 | | WN66_00017

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[+]  | YAL055W~PEX22,YAF5~Verified | WN66_00018 | protein_coding | Gene | gene17 | SGD:S000000051 | Putative peroxisomal membrane protein; required for import of peroxisomal proteins; functionally complements a Pichia pastoris pex22 mutation | PEX22 | | WN66_00018

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[+]  | YAL054C~ACS1,FUN44~Verified | WN66_00019 | protein_coding | Gene | gene18 | SGD:S000000050 | Acetyl-coA synthetase isoform; along with Acs2p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions | ACS1 | | WN66_00019

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[+]  | YAL053W~FLC2,HUF2~Verified | WN66_00020 | protein_coding | Gene | gene19 | SGD:S000000049 | Putative calcium channel involved in calcium release under hypotonic stress; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication | FLC2 | | WN66_00020

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[+]  | YAL051W~OAF1,YAF1~Verified | WN66_00021 | protein_coding | Gene | gene20 | SGD:S000000048 | Oleate-activated transcription factor; subunit of a heterodimeric complex with Pip2p, which binds to oleate-response elements (ORE) in the promoter of genes involved in beta-oxidation of fatty acids, peroxisome organization and biogenesis, activating transcription in the presence of oleate; regulates chromatin silencing at telomeres; involved in diauxic shift; OAF1 has a paralog, PIP2, that arose from the whole genome duplication | OAF1 | | WN66_00021

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[+]  | YAL049C~AIM2~Verified | WN66_00022 | protein_coding | Gene | gene21 | SGD:S000000047 | Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor | AIM2 | | WN66_00022

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[+]  | YAL048C~GEM1,GON1~Verified | WN66_00023 | protein_coding | Gene | gene22 | SGD:S000000046 | Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases | GEM1 | | WN66_00023

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[+]  | YAL047W-A~Dubious | WN66_00024 | protein_coding | Gene | gene23 | SGD:S000028733 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF GEM1/YAL048C | | | WN66_00024

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[+]  | YAL047C~SPC72,LDB4~Verified | WN66_00025 | protein_coding | Gene | gene24 | SGD:S000000045 | Gamma-tubulin small complex (gamma-TuSC) receptor; recruits the gamma-TuSC complex to the cytoplasmic side of the SPB, connecting nuclear microtubules to the SPB; involved in astral microtubule formation, stabilization, and with Stu2p, anchoring astral MTs at the cytoplasmic face of the SPB, and regulating plus-end MT dynamics; regulated by Cdc5 kinase | SPC72 | | WN66_00025

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[+]  | YAL046C~AIM1~Verified | WN66_00026 | protein_coding | Gene | gene25 | SGD:S000000044 | Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress by acting along with Nfu1p at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to mitochondrial client proteins like lipoate synthase and succinate dehydrogenase; sequence similarity to human BOLA family member, BOLA3, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS2) | BOL3 | | WN66_00026

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[+]  | YAL045C~Dubious | WN66_00027 | protein_coding | Gene | gene26 | SGD:S000000043 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A | | | WN66_00027

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[+]  | YAL044W-A~Uncharacterized | WN66_00028 | protein_coding | Gene | gene27 | SGD:S000007586 | Mitochondrial matrix protein involved in Fe-S cluster biogenesis; facilitates [4Fe-2S] cluster inception into mitochondrial proteins such as lipoate synthase and succinate dehydrogenase; interacts and may function with Grx5p at an early step in Fe-S cluster biosynthesis; forms dimeric complexes with Grx5p and Nfu1p that alter the stability of shared Fe/S clusters; sequence similarity to human BOLA family member, BOLA1 and S. pombe uvi31, a putative DNA repair protein | BOL1 | | WN66_00028

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[+]  | YAL044C~GCV3~Verified | WN66_00029 | protein_coding | Gene | gene28 | SGD:S000000042 | H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF | GCV3 | | WN66_00029

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[+]  | YAL043C~PTA1,FUN39~Verified | WN66_00030 | protein_coding | Gene | gene29 | SGD:S000000041 | Subunit of holo-CPF; holo-CPF is a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII | PTA1 | | WN66_00030

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[+]  | YAL042C-A~YAL043C-A~Dubious | WN66_00031 | protein_coding | Gene | gene30 | SGD:S000002138 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene | | | WN66_00031

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[+]  | YAL042W~ERV46,FUN9~Verified | WN66_00032 | protein_coding | Gene | gene31 | SGD:S000000040 | Protein localized to COPII-coated vesicles; forms a complex with Erv41p; involved in the membrane fusion stage of transport | ERV46 | | WN66_00032

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[+]  | YAL041W~CDC24,CLS4~Verified | WN66_00033 | protein_coding | Gene | gene32 | SGD:S000000039 | Guanine nucleotide exchange factor (GEF) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress; thermosensitivity of the cdc24-4 mutant in the presence of sorbitol is functionally complemented by human CDC42 | CDC24 | | WN66_00033

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[+]  | YAL040C~CLN3,DAF1,FUN10,WHI1~Verified | WN66_00034 | protein_coding | Gene | gene33 | SGD:S000000038 | G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote G1 to S phase transition; plays a role in regulating transcription of other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; acetyl-CoA induces CLN3 transcription in response to nutrient repletion to promote cell-cycle entry; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1 | CLN3 | | WN66_00034

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[+]  | YAL039C~CYC3~Verified | WN66_00035 | protein_coding | Gene | gene34 | SGD:S000000037 | Cytochrome c heme lyase (holocytochrome c synthase); attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in mitochondrial intermembrane space; human homolog HCCS implicated in microphthalmia with linear skin defects (MLS), and can complement yeast null mutant | CYC3 | | WN66_00035

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[+]  | YAL038W~CDC19,PYK1~Verified | WN66_00036 | protein_coding | Gene | gene35 | SGD:S000000036 | Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication | CDC19 | | WN66_00036

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[+]  | YAL037C-B~Dubious | WN66_00037 | protein_coding | Gene | gene36 | SGD:S000028592 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching | | | WN66_00037

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[+]  | YAL037C-A~Uncharacterized | WN66_00038 | protein_coding | Gene | gene37 | SGD:S000028732 | Putative protein of unknown function | | | WN66_00038

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[+]  | YAL037W~Uncharacterized | WN66_00039 | protein_coding | Gene | gene38 | SGD:S000000035 | Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication | | | WN66_00039

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[+]  | YAL036C~RBG1,FUN11~Verified | WN66_00040 | protein_coding | Gene | gene39 | SGD:S000000034 | Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid | RBG1 | | WN66_00040

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[+]  | YAL035W~FUN12,yIF2~Verified | WN66_00041 | protein_coding | Gene | gene40 | SGD:S000000033 | Translation initiation factor eIF5B; GTPase that promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; promotes GTP-dependent maturation of 18S rRNA by Nob1p; protein abundance increases in response to DNA replication stress; homolog of bacterial IF2 | FUN12 | | WN66_00041

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[+]  | YAL034C-B~YAL035C-A~Dubious | WN66_00042 | pseudogene | Gene | gene41 | SGD:S000002137 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | true | WN66_00042

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[+]  | YAL034W-A~MTW1,DSN3,NSL2~Verified | WN66_00043 | protein_coding | Gene | gene42 | SGD:S000000032 | Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND) | MTW1 | | WN66_00043

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[+]  | YAL034C~FUN19~Verified | WN66_00044 | protein_coding | Gene | gene43 | SGD:S000002134 | Non-essential protein of unknown function; expression induced in response to heat stress; FUN19 has a paralog, YOR338W, that arose from the whole genome duplication | FUN19 | | WN66_00044

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[+]  | YAL033W~POP5,FUN53~Verified | WN66_00045 | protein_coding | Gene | gene44 | SGD:S000000031 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs | POP5 | | WN66_00045

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[+]  | YAL032C~PRP45,FUN20~Verified | WN66_00046 | protein_coding | Gene | gene45 | SGD:S000000030 | Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene | PRP45 | | WN66_00046

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[+]  | YAL031W-A~Dubious | WN66_00047 | pseudogene | Gene | gene46 | SGD:S000028731 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF GIP4/YAL031C | | true | WN66_00047

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[+]  | YAL031C~GIP4,FUN21~Verified | WN66_00048 | protein_coding | Gene | gene47 | SGD:S000000029 | Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; protein overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate | GIP4 | | WN66_00048

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[+]  | YAL030W~SNC1~Verified | WN66_00049 | protein_coding | Gene | gene48 | SGD:S000000028 | Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication | SNC1 | | WN66_00049

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[+]  | YAL029C~MYO4,FUN22,SHE1~Verified | WN66_00050 | protein_coding | Gene | gene49 | SGD:S000000027 | Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication | MYO4 | | WN66_00050

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