Feature Listing

[+]  | tS(AGA)A | WN66_00098 | tRNA | Gene | gene97 | | | | | WN66_00098

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[+]  | YAL064W~Verified | WN66_00111 | pseudogene | Gene | gene110 | | | | true | WN66_00111

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[+]  | hYIR044C | WN66_00005 | pseudogene | Gene | gene4 | | | | true | WN66_00005

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[+]  FLO59 | YAL063C | FLO59 | protein_coding | Gene | gene7 | | | | | WN66_00008

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[+]  | YAR023C~Uncharacterized | WN66_00096 | protein_coding | Gene | gene95 | SGD:S000000074 | Putative integral membrane protein; member of DUP240 gene family | | | WN66_00096

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[+]  | YAR030C~Dubious | WN66_00102 | pseudogene | Gene | gene101 | SGD:S000001821 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 | | true | WN66_00102

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[+]  | YAR035C-A~Uncharacterized | WN66_00106 | protein_coding | Gene | gene105 | SGD:S000028595 | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational "guilt by association" analysis | | | WN66_00106

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[+]  | YAR047C~Dubious | WN66_00108 | protein_coding | Gene | gene107 | SGD:S000000083 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | | WN66_00108

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[+]  | YAR060C~Dubious | WN66_00112 | protein_coding | Gene | gene111 | SGD:S000000086 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YAR060C has a paralog, YHR212C, that arose from a segmental duplication | | | WN66_00112

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[+]  | YAR070C~Dubious | WN66_00119 | protein_coding | Gene | gene118 | SGD:S000000093 | Dubious open reading frame; unlikely to encode a protein, based on available experimental and comparative sequence data; YAR070C has a paralog, YHR214C-B, that arose from a segmental duplication | | | WN66_00119

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[+]  | YAL016C-B~Dubious | WN66_00065 | protein_coding | Gene | gene64 | SGD:S000028528 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | | WN66_00065

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[+]  | YAL016C-A~Dubious | WN66_00066 | protein_coding | Gene | gene65 | SGD:S000028728 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF TPD3/YAL016W | | | WN66_00066

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[+]  | YAL034C-B~YAL035C-A~Dubious | WN66_00042 | pseudogene | Gene | gene41 | SGD:S000002137 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | true | WN66_00042

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[+]  | YAL056C-A~YAL058C-A~Dubious | WN66_00016 | protein_coding | Gene | gene15 | SGD:S000002139 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | | WN66_00016

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[+]  | YAL045C~Dubious | WN66_00027 | protein_coding | Gene | gene26 | SGD:S000000043 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A | | | WN66_00027

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[+]  | YAL042C-A~YAL043C-A~Dubious | WN66_00031 | protein_coding | Gene | gene30 | SGD:S000002138 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene | | | WN66_00031

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[+]  | YAL037C-B~Dubious | WN66_00037 | protein_coding | Gene | gene36 | SGD:S000028592 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching | | | WN66_00037

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[+]  | YAL037C-A~Uncharacterized | WN66_00038 | protein_coding | Gene | gene37 | SGD:S000028732 | Putative protein of unknown function | | | WN66_00038

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[+]  | YAL059C-A~Dubious | WN66_00013 | protein_coding | Gene | gene12 | SGD:S000028734 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene ECM1/YAL059W | | | WN66_00013

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[+]  | YAR069C~Dubious | WN66_00118 | protein_coding | Gene | gene117 | SGD:S000000092 | Dubious open reading frame; unlikely to encode a protein, based on available experimental and comparative sequence data; YAR069C has a paralog, YHR214C-D, that arose from a segmental duplication | | | WN66_00118

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[+]  | YAR018C~KIN3,FUN52,NPK1~Verified | WN66_00092 | protein_coding | Gene | gene91 | SGD:S000000071 | Nonessential serine/threonine protein kinase; possible role in DNA damage response; influences tolerance to high levels of ethanol | KIN3 | | WN66_00092

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[+]  | YAR019C~CDC15,LYT1~Verified | WN66_00093 | protein_coding | Gene | gene92 | SGD:S000000072 | Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress | CDC15 | | WN66_00093

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[+]  | YAR020C~PAU7~Verified | WN66_00095 | protein_coding | Gene | gene94 | SGD:S000000073 | Member of the seripauperin multigene family; active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme | PAU7 | | WN66_00095

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[+]  | YAL021C~CCR4,FUN27,NUT21~Verified | WN66_00059 | protein_coding | Gene | gene58 | SGD:S000000019 | Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening | CCR4 | | WN66_00059

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[+]  | YAL020C~ATS1,FUN28,KTI13~Verified | WN66_00060 | protein_coding | Gene | gene59 | SGD:S000000018 | Protein required for modification of wobble nucleosides in tRNA; acts with Elongator complex, Kti11p, and Kti12p; has a potential role in regulatory interactions between microtubules and the cell cycle; forms a stable heterodimer with Kti11p | ATS1 | | WN66_00060

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[+]  | YAL018C~Verified | WN66_00063 | protein_coding | Gene | gene62 | SGD:S000000016 | Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds2p and Rrt8p, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants | LDS1 | | WN66_00063

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[+]  | YAL036C~RBG1,FUN11~Verified | WN66_00040 | protein_coding | Gene | gene39 | SGD:S000000034 | Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid | RBG1 | | WN66_00040

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[+]  | YAL034C~FUN19~Verified | WN66_00044 | protein_coding | Gene | gene43 | SGD:S000002134 | Non-essential protein of unknown function; expression induced in response to heat stress; FUN19 has a paralog, YOR338W, that arose from the whole genome duplication | FUN19 | | WN66_00044

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[+]  | YAL032C~PRP45,FUN20~Verified | WN66_00046 | protein_coding | Gene | gene45 | SGD:S000000030 | Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene | PRP45 | | WN66_00046

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[+]  | YAL054C~ACS1,FUN44~Verified | WN66_00019 | protein_coding | Gene | gene18 | SGD:S000000050 | Acetyl-coA synthetase isoform; along with Acs2p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions | ACS1 | | WN66_00019

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[+]  | YAL049C~AIM2~Verified | WN66_00022 | protein_coding | Gene | gene21 | SGD:S000000047 | Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor | AIM2 | | WN66_00022

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[+]  | YAL048C~GEM1,GON1~Verified | WN66_00023 | protein_coding | Gene | gene22 | SGD:S000000046 | Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases | GEM1 | | WN66_00023

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[+]  | YAL047C~SPC72,LDB4~Verified | WN66_00025 | protein_coding | Gene | gene24 | SGD:S000000045 | Gamma-tubulin small complex (gamma-TuSC) receptor; recruits the gamma-TuSC complex to the cytoplasmic side of the SPB, connecting nuclear microtubules to the SPB; involved in astral microtubule formation, stabilization, and with Stu2p, anchoring astral MTs at the cytoplasmic face of the SPB, and regulating plus-end MT dynamics; regulated by Cdc5 kinase | SPC72 | | WN66_00025

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[+]  | YAL046C~AIM1~Verified | WN66_00026 | protein_coding | Gene | gene25 | SGD:S000000044 | Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress by acting along with Nfu1p at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to mitochondrial client proteins like lipoate synthase and succinate dehydrogenase; sequence similarity to human BOLA family member, BOLA3, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS2) | BOL3 | | WN66_00026

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[+]  | YAL044C~GCV3~Verified | WN66_00029 | protein_coding | Gene | gene28 | SGD:S000000042 | H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF | GCV3 | | WN66_00029

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[+]  | YAL043C~PTA1,FUN39~Verified | WN66_00030 | protein_coding | Gene | gene29 | SGD:S000000041 | Subunit of holo-CPF; holo-CPF is a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII | PTA1 | | WN66_00030

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[+]  | YAL040C~CLN3,DAF1,FUN10,WHI1~Verified | WN66_00034 | protein_coding | Gene | gene33 | SGD:S000000038 | G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote G1 to S phase transition; plays a role in regulating transcription of other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; acetyl-CoA induces CLN3 transcription in response to nutrient repletion to promote cell-cycle entry; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1 | CLN3 | | WN66_00034

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[+]  | YAL039C~CYC3~Verified | WN66_00035 | protein_coding | Gene | gene34 | SGD:S000000037 | Cytochrome c heme lyase (holocytochrome c synthase); attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in mitochondrial intermembrane space; human homolog HCCS implicated in microphthalmia with linear skin defects (MLS), and can complement yeast null mutant | CYC3 | | WN66_00035

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[+]  | YAL067C~SEO1~Verified | WN66_00006 | protein_coding | Gene | gene5 | SGD:S000000062 | Putative permease; member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide | SEO1 | | WN66_00006

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[+]  | YAL015C~NTG1,FUN33,SCR1,ogg2~Verified | WN66_00068 | protein_coding | Gene | gene67 | SGD:S000000013 | DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication | NTG1 | | WN66_00068

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[+]  | YAL014C~SYN8,SLT2,UIP2~Verified | WN66_00069 | protein_coding | Gene | gene68 | SGD:S000000012 | Endosomal SNARE related to mammalian syntaxin 8 | SYN8 | | WN66_00069

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[+]  | YAL010C~MDM10,FUN37~Verified | WN66_00073 | protein_coding | Gene | gene72 | SGD:S000000008 | Subunit of both the ERMES and the SAM complex; component of ERMES complex which acts as a molecular tether between the mitochondria and the ER, necessary for efficient phospholipid exchange between organelles and for mitophagy; SAM/TOB complex component that functions in the assembly of outer membrane beta-barrel proteins; involved in mitochondrial inheritance and morphology; ERMES complex is often co-localized with peroxisomes and concentrated areas of pyruvate dehydrogenase | MDM10 | | WN66_00073

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[+]  | YAL007C~ERP2~Verified | WN66_00076 | protein_coding | Gene | gene75 | SGD:S000000005 | Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP2 has a paralog, ERP4, that arose from the whole genome duplication | ERP2 | | WN66_00076

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[+]  | YAL005C~SSA1,YG100~Verified | WN66_00078 | protein_coding | Gene | gene77 | SGD:S000000004 | ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; required for ubiquitin-dependent degradation of short-lived proteins; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, cell wall; 98% identical to paralog Ssa2p with different functional specificity in propagation of yeast [URE3] prions, vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils | SSA1 | | WN66_00078

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[+]  | YAL001C~TFC3,FUN24,TSV115~Verified | WN66_00083 | protein_coding | Gene | gene82 | SGD:S000000001 | Subunit of RNA polymerase III transcription initiation factor complex; part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding; largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC) | TFC3 | | WN66_00083

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[+]  | YAR002C-A~ERP1~Verified | WN66_00085 | protein_coding | Gene | gene84 | SGD:S000002129 | Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication | ERP1 | | WN66_00085

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[+]  | YAR007C~RFA1,BUF2,FUN3,RPA1~Verified | WN66_00087 | protein_coding | Gene | gene86 | SGD:S000000065 | Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; role in DNA catenation/decatenation pathway of chromosome disentangling; relocalizes to the cytosol in response to hypoxia | RFA1 | | WN66_00087

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[+]  | YAR014C~BUD14~Verified | WN66_00090 | protein_coding | Gene | gene89 | SGD:S000000069 | Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; forms a complex with Kel1p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress | BUD14 | | WN66_00090

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[+]  | YAL031C~GIP4,FUN21~Verified | WN66_00048 | protein_coding | Gene | gene47 | SGD:S000000029 | Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; protein overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate | GIP4 | | WN66_00048

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[+]  | YAL029C~MYO4,FUN22,SHE1~Verified | WN66_00050 | protein_coding | Gene | gene49 | SGD:S000000027 | Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication | MYO4 | | WN66_00050

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