Feature Listing

[+]  WN66_00173 | gene174 | WN66_00173 | protein_coding | Gene | YBL071C-B~Uncharacterized | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching | SGD:S000028597 | |

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[+]  WN66_00174 | gene175 | WN66_00174 | protein_coding | Gene | YBL071W-A~KTI11,DPH3~Verified | Zn-ribbon protein that co-purifies with Dph1 and Dph2; in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p; involved in modification of wobble nucleosides in tRNAs; forms a stable heterodimer with Ats1p | SGD:S000007587 | KTI11 |

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[+]  WN66_00175 | gene176 | WN66_00175 | protein_coding | Gene | YBL071C~Dubious | Putative protein of unknown function; conserved among S. cerevisiae strains; YBL071C is not an essential gene | SGD:S000000167 | |

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[+]  WN66_00176 | gene177 | WN66_00176 | pseudogene | Gene | YBL070C~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | SGD:S000000166 | | true

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[+]  WN66_00177 | gene178 | WN66_00177 | protein_coding | Gene | YBL069W~AST1~Verified | Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication | SGD:S000000165 | AST1 |

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[+]  WN66_00178 | gene179 | WN66_00178 | protein_coding | Gene | YBL068W~PRS4~Verified | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic | SGD:S000000164 | PRS4 |

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[+]  WN66_00179 | gene180 | WN66_00179 | protein_coding | Gene | YBL067C~UBP13~Verified | Ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication | SGD:S000000163 | UBP13 |

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[+]  WN66_00180 | gene181 | WN66_00180 | protein_coding | Gene | YBL066C~SEF1~Verified | Putative transcription factor; has homolog in Kluyveromyces lactis | SGD:S000000162 | SEF1 |

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[+]  WN66_00181 | gene182 | WN66_00181 | protein_coding | Gene | YBL065W~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene | SGD:S000000161 | |

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[+]  WN66_00182 | gene183 | WN66_00182 | protein_coding | Gene | YBL064C~PRX1~Verified | Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress | SGD:S000000160 | PRX1 |

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[+]  WN66_00183 | gene184 | WN66_00183 | protein_coding | Gene | YBL063W~KIP1,CIN9~Verified | Kinesin-related motor protein; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions | SGD:S000000159 | KIP1 |

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[+]  WN66_00184 | gene185 | WN66_00184 | protein_coding | Gene | YBL062W~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | SGD:S000000158 | |

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[+]  WN66_00185 | gene186 | WN66_00185 | protein_coding | Gene | YBL061C~SKT5,CAL2,CHS4,CSD4~Verified | Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication | SGD:S000000157 | SKT5 |

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[+]  WN66_00186 | gene187 | WN66_00186 | protein_coding | Gene | YBL060W~YEL1~Verified | Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip | SGD:S000000156 | YEL1 |

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[+]  WN66_00187 | gene188 | WN66_00187 | protein_coding | Gene | YBL059C-A~CMC2~Verified | Protein involved in respiratory chain complex assembly or maintenance; protein of the mitochondrial intermembrane space; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold | SGD:S000007488 | CMC2 |

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[+]  WN66_00188 | gene189 | WN66_00188 | protein_coding | Gene | YBL059W~Uncharacterized | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication | SGD:S000000155 | |

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[+]  WN66_00189 | gene190 | WN66_00189 | protein_coding | Gene | YBL058W~SHP1,UBX1~Verified | UBX domain-containing substrate adaptor for Cdc48p; ubiquitin regulatory X domain-containing protein that acts as a substrate recruiting cofactor for Cdc48p; positively regulates Glc7p PPase activity to promote growth and mitotic progression in complex with Cdc48p; ubiquitinated protein interactor involved in ER-associated degradation (ERAD); regulated by nuclear Ub-dependent degradation (INMAD pathway) independent of the Asi and Doa10 complexes; homolog of human p47 (NSFL1C) | SGD:S000000154 | SHP1 |

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[+]  WN66_00190 | gene191 | WN66_00190 | protein_coding | Gene | YBL057C~PTH2~Verified | One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1 | SGD:S000000153 | PTH2 |

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[+]  WN66_00191 | gene192 | WN66_00191 | protein_coding | Gene | YBL056W~PTC3~Verified | Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication | SGD:S000000152 | PTC3 |

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[+]  WN66_00192 | gene193 | WN66_00192 | protein_coding | Gene | YBL055C~Tat-D~Verified | 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases | SGD:S000000151 | |

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[+]  WN66_00193 | gene194 | WN66_00193 | protein_coding | Gene | YBL054W~TOD6,PBF1~Verified | PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; activated in stochastic pulses of nuclear localization | SGD:S000000150 | TOD6 |

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[+]  WN66_00194 | gene195 | WN66_00194 | protein_coding | Gene | YBL053W~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | SGD:S000000149 | |

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[+]  WN66_00195 | gene196 | WN66_00195 | protein_coding | Gene | YBL052C~SAS3~Verified | Histone acetyltransferase catalytic subunit of NuA3 complex; acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal | SGD:S000000148 | SAS3 |

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[+]  WN66_00196 | gene197 | WN66_00196 | protein_coding | Gene | YBL051C~PIN4,MDT1~Verified | Protein involved in G2/M phase progression and response to DNA damage; interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage | SGD:S000000147 | PIN4 |

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[+]  WN66_00197 | gene198 | WN66_00197 | protein_coding | Gene | YBL050W~SEC17,RNS3~Verified | Alpha-SNAP cochaperone; SNARE-complex adaptor for Sec18 (NSF) during the disassembly of postfusion cis-SNARE complexes; stimulates the ATPase activity of Sec18p; peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; similar to mammalian alpha-SNAP | SGD:S000000146 | SEC17 |

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[+]  WN66_00198 | gene199 | WN66_00198 | protein_coding | Gene | YBL049W~MOH1~Verified | Protein of unknown function, essential for stationary phase survival; not required for growth on nonfermentable carbon sources; possibly linked with vacuolar transport | SGD:S000000145 | MOH1 |

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[+]  WN66_00199 | gene200 | WN66_00199 | protein_coding | Gene | YBL048W~RRT1~Dubious | Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data | SGD:S000000144 | RRT1 |

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[+]  WN66_00200 | gene201 | WN66_00200 | protein_coding | Gene | YBL047C~EDE1,BUD15~Verified | Scaffold protein involved in the formation of early endocytic sites; putative regulator of cytokinesis; homo-oligomerization is required for localization to and organization of endocytic sites; has a network of interactions with other endocytic proteins; binds membranes in a ubiquitin-dependent manner; may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death; homolog of mammalian Eps15 | SGD:S000000143 | EDE1 |

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[+]  WN66_00201 | gene202 | WN66_00201 | protein_coding | Gene | YBL046W~PSY4~Verified | Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2 | SGD:S000000142 | PSY4 |

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[+]  WN66_00202 | gene203 | WN66_00202 | protein_coding | Gene | YBL045C~COR1,QCR1~Verified | Core subunit of the ubiquinol-cytochrome c reductase complex; the ubiquinol-cytochrome c reductase complex (bc1 complex) is a component of the mitochondrial inner membrane electron transport chain | SGD:S000000141 | COR1 |

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[+]  WN66_00203 | gene204 | WN66_00203 | protein_coding | Gene | YBL044W~Uncharacterized | Putative protein of unknown function; YBL044W is not an essential protein | SGD:S000000140 | |

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[+]  WN66_00204 | gene205 | WN66_00204 | protein_coding | Gene | YBL043W~ECM13~Verified | Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication | SGD:S000000139 | ECM13 |

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[+]  WN66_00205 | gene206 | WN66_00205 | protein_coding | Gene | YBL042C~FUI1~Verified | High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress | SGD:S000000138 | FUI1 |

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[+]  WN66_00206 | gene207 | WN66_00206 | protein_coding | Gene | YBL041W~PRE7,PRS3~Verified | Beta 6 subunit of the 20S proteasome | SGD:S000000137 | PRE7 |

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[+]  WN66_00207 | gene208 | WN66_00207 | protein_coding | Gene | YBL040C~ERD2~Verified | HDEL receptor; an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins | SGD:S000000136 | ERD2 |

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[+]  WN66_00208 | gene209 | WN66_00208 | protein_coding | Gene | YBL039W-B~YBL039W-A~Uncharacterized | Putative protein of unknown function; mCherry fusion protein localizes to the vacuole | SGD:S000028517 | |

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[+]  WN66_00209 | gene210 | WN66_00209 | protein_coding | Gene | YBL039C~URA7~Verified | Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication | SGD:S000000135 | URA7 |

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[+]  WN66_00210 | gene211 | WN66_00210 | protein_coding | Gene | YBL038W~MRPL16~Verified | Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L16 ribosomal protein; synthetic lethality with hac1 mutation suggests a possible role in synthesis of precursors for protein glycosylation | SGD:S000000134 | MRPL16 |

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[+]  WN66_00211 | gene212 | WN66_00211 | protein_coding | Gene | YBL037W~APL3~Verified | Alpha-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport | SGD:S000000133 | APL3 |

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[+]  WN66_00212 | gene213 | WN66_00212 | protein_coding | Gene | YBL036C~Verified | Putative non-specific single-domain racemase; based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS | SGD:S000000132 | |

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[+]  WN66_00213 | gene214 | WN66_00213 | protein_coding | Gene | YBL035C~POL12~Verified | B subunit of DNA polymerase alpha-primase complex; required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation | SGD:S000000131 | POL12 |

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[+]  WN66_00214 | gene215 | WN66_00214 | protein_coding | Gene | YBL034C~STU1~Verified | Component of the mitotic spindle; binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles | SGD:S000000130 | STU1 |

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[+]  WN66_00215 | gene216 | WN66_00215 | protein_coding | Gene | YBL033C~RIB1~Verified | GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway | SGD:S000000129 | RIB1 |

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[+]  WN66_00216 | gene217 | WN66_00216 | protein_coding | Gene | YBL032W~HEK2,KHD1~Verified | RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K | SGD:S000000128 | HEK2 |

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[+]  WN66_00217 | gene218 | WN66_00217 | protein_coding | Gene | YBL031W~SHE1~Verified | Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function | SGD:S000000127 | SHE1 |

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[+]  WN66_00218 | gene219 | WN66_00218 | protein_coding | Gene | YBL030C~PET9,AAC2,ANC2,OP1~Verified | Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication; human homolog SLC25A4 implicated in progressive external ophthalmoplegia can complement yeast null mutant | SGD:S000000126 | PET9 |

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[+]  WN66_00219 | gene220 | WN66_00219 | protein_coding | Gene | YBL029C-A~Verified | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica | SGD:S000007591 | |

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[+]  WN66_00220 | gene221 | WN66_00220 | protein_coding | Gene | YBL029W~Uncharacterized | Non-essential protein of unknown function | SGD:S000000125 | |

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[+]  WN66_00221 | gene222 | WN66_00221 | protein_coding | Gene | YBL028C~Verified | Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis | SGD:S000000124 | |

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[+]  WN66_00222 | gene223 | WN66_00222 | protein_coding | Gene | YBL027W~RPL19B~Verified | Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication | SGD:S000000123 | RPL19B |

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