Feature Listing

[+]  WN66_00223 | gene224 | WN66_00223 | protein_coding | Gene | Scer_YGOB_YBL026W-A | | | |

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[+]  WN66_00224 | gene225 | WN66_00224 | protein_coding | Gene | YBL026W~LSM2,SMX5,SNP3~Verified | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress | SGD:S000000122 | LSM2 |

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[+]  WN66_00225 | gene226 | WN66_00225 | protein_coding | Gene | YBL025W~RRN10~Verified | Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I | SGD:S000000121 | RRN10 |

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[+]  WN66_00226 | gene227 | WN66_00226 | protein_coding | Gene | YBL024W~NCL1,TRM4~Verified | S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120 | SGD:S000000120 | NCL1 |

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[+]  WN66_00227 | gene228 | WN66_00227 | protein_coding | Gene | YBL023C~MCM2~Verified | Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress | SGD:S000000119 | MCM2 |

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[+]  WN66_00228 | gene229 | WN66_00228 | protein_coding | Gene | YBL022C~PIM1,LON1~Verified | ATP-dependent Lon protease; involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria | SGD:S000000118 | PIM1 |

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[+]  WN66_00229 | gene230 | WN66_00229 | protein_coding | Gene | YBL021C~HAP3~Verified | Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding | SGD:S000000117 | HAP3 |

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[+]  WN66_00230 | gene231 | WN66_00230 | protein_coding | Gene | YBL020W~RFT1~Verified | Membrane protein required for translocation of Man5GlcNac2-PP-Dol; required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein; essential gene | SGD:S000000116 | RFT1 |

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[+]  WN66_00231 | gene232 | WN66_00231 | protein_coding | Gene | YBL019W~APN2,ETH1~Verified | Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII | SGD:S000000115 | APN2 |

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[+]  WN66_00232 | gene233 | WN66_00232 | protein_coding | Gene | YBL018C~Verified | | | |

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[+]  WN66_00233 | gene234 | WN66_00233 | protein_coding | Gene | YBL017C~PEP1,VPS10,VPT1~Verified | Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments | SGD:S000000113 | PEP1 |

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[+]  WN66_00234 | gene235 | WN66_00234 | protein_coding | Gene | YBL016W~FUS3,DAC2~Verified | Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis | SGD:S000000112 | FUS3 |

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[+]  WN66_00235 | gene236 | WN66_00235 | protein_coding | Gene | YBL015W~ACH1~Verified | Protein with CoA transferase activity; particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth | SGD:S000000111 | ACH1 |

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[+]  WN66_00236 | gene237 | WN66_00236 | tRNA | Gene | tI(AAU)B | | | |

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[+]  WN66_00237 | gene238 | WN66_00237 | tRNA | Gene | tG(GCC)B | | | |

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[+]  WN66_00238 | gene239 | WN66_00238 | protein_coding | Gene | YBL014C~RRN6~Verified | Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p | SGD:S000000110 | RRN6 |

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[+]  WN66_00239 | gene240 | WN66_00239 | protein_coding | Gene | YBL013W~FMT1~Verified | Methionyl-tRNA formyltransferase; catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate | SGD:S000000109 | FMT1 |

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[+]  WN66_00240 | gene241 | WN66_00240 | protein_coding | Gene | YBL012C~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | SGD:S000000108 | |

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[+]  WN66_00241 | gene242 | WN66_00241 | protein_coding | Gene | YBL011W~SCT1,GAT2~Verified | Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; dual substrate-specific acyltransferase of the glycerolipid biosynthesis pathway; prefers 16-carbon fatty acids; similar to Gpt2p; gene is constitutively transcribed | SGD:S000000107 | SCT1 |

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[+]  WN66_00242 | gene243 | WN66_00242 | protein_coding | Gene | YBL010C~Uncharacterized | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles | SGD:S000000106 | |

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[+]  WN66_00243 | gene244 | WN66_00243 | protein_coding | Gene | YBL009W~ALK2~Verified | Protein kinase; along with its paralog, ALK1, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of cell polarity factors in mitosis, proper localization of formins and polarity factors, and survival in cells that activate spindle assembly checkpoint; phosphorylated in response to DNA damage; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins | SGD:S000000105 | ALK2 |

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[+]  WN66_00244 | gene245 | WN66_00244 | protein_coding | Gene | YBL008W-A~Uncharacterized | Putative protein of unknown function; identified by fungal homology and RT-PCR | SGD:S000028529 | |

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[+]  WN66_00245 | gene246 | WN66_00245 | protein_coding | Gene | YBL008W~HIR1~Verified | Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores | SGD:S000000104 | HIR1 |

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[+]  WN66_00246 | gene247 | WN66_00246 | protein_coding | Gene | YBL007C~SLA1~Verified | Cytoskeletal protein binding protein; required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains | SGD:S000000103 | SLA1 |

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[+]  WN66_00247 | gene248 | WN66_00247 | protein_coding | Gene | YBL006C~LDB7,RSC14~Verified | Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions | SGD:S000000102 | LDB7 |

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[+]  WN66_00248 | gene249 | WN66_00248 | protein_coding | Gene | YBL006W-A~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene LDB7/YBL006C | SGD:S000028596 | |

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[+]  WN66_00249 | gene250 | WN66_00249 | protein_coding | Gene | YBL005W~PDR3,AMY2,TPE2~Verified | Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting PDRE sites (PDR responsive elements); has a role in response to drugs and organic solvents; post-translationally up-regulated in cells lacking functional mitochondrial genome; involved in diauxic shift; relative distribution to nucleus increases upon DNA replication stress; APCC(Cdh1) substrate | SGD:S000000101 | PDR3 |

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[+]  WN66_00250 | gene251 | WN66_00250 | tRNA | Gene | tS(AGA)B | | | |

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[+]  WN66_00251 | gene252 | WN66_00251 | protein_coding | Gene | YBL004W~UTP20~Verified | Component of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA | SGD:S000000100 | UTP20 |

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[+]  WN66_00252 | gene253 | WN66_00252 | protein_coding | Gene | YBL003C~HTA2,H2A2~Verified | Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p | SGD:S000000099 | HTA2 |

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[+]  WN66_00253 | gene254 | WN66_00253 | protein_coding | Gene | YBL002W~HTB2~Verified | Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA replication, transcriptional activation, meiotic DSB formation and H3 methylation | SGD:S000000098 | HTB2 |

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[+]  WN66_00254 | gene255 | WN66_00254 | protein_coding | Gene | YBL001C~ECM15~Verified | Non-essential protein of unknown function; likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis | SGD:S000000097 | ECM15 |

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[+]  WN66_00255 | gene256 | WN66_00255 | protein_coding | Gene | YBR001C~NTH2~Verified | Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication | SGD:S000000205 | NTH2 |

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[+]  WN66_00256 | gene257 | WN66_00256 | protein_coding | Gene | YBR002C~RER2~Verified | Forms the dehydrodolichyl diphosphate syntase (DDS) complex with NUS1; major enzyme of polyprenol synthesis in both the endoplasmic reticulum (ER) and in lipid droplets; participates in ER protein sorting; human ortholog DHDDS functionally complements the heat sensitive growth defect of a ts allele, and is associated with retinitis pigmentosa | SGD:S000000206 | RER2 |

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[+]  WN66_00257 | gene258 | WN66_00257 | protein_coding | Gene | YBR003W~COQ1~Verified | Hexaprenyl pyrophosphate synthetase; catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis | SGD:S000000207 | COQ1 |

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[+]  WN66_00258 | gene259 | WN66_00258 | protein_coding | Gene | YBR004C~GPI18,FMP44~Verified | Functional ortholog of human PIG-V; PIG-V is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria | SGD:S000000208 | GPI18 |

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[+]  WN66_00259 | gene260 | WN66_00259 | protein_coding | Gene | YBR005W~RCR1,SSH6~Verified | Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication | SGD:S000000209 | RCR1 |

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[+]  WN66_00260 | gene261 | WN66_00260 | protein_coding | Gene | YBR006W~UGA2,UGA5~Verified | Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm | SGD:S000000210 | UGA2 |

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[+]  WN66_00261 | gene262 | WN66_00261 | protein_coding | Gene | YBR007C~DSF2~Verified | Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress | SGD:S000000211 | DSF2 |

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[+]  WN66_00262 | gene263 | WN66_00262 | protein_coding | Gene | YBR008C~FLR1~Verified | Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress | SGD:S000000212 | FLR1 |

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[+]  WN66_00263 | gene264 | WN66_00263 | protein_coding | Gene | YBR009C~HHF1~Verified | Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity | SGD:S000000213 | HHF1 |

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[+]  WN66_00264 | gene265 | WN66_00264 | protein_coding | Gene | YBR010W~HHT1,BUR5,SIN2~Verified | Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage | SGD:S000000214 | HHT1 |

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[+]  WN66_00265 | gene266 | WN66_00265 | protein_coding | Gene | YBR011C~IPP1,PPA1~Verified | Cytoplasmic inorganic pyrophosphatase (PPase); homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase | SGD:S000000215 | IPP1 |

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[+]  WN66_00266 | gene267 | WN66_00266 | tRNA | Gene | tT(AGU)B | | | |

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[+]  WN66_00267 | gene268 | WN66_00267 | protein_coding | Gene | YBR014C~GRX7~Verified | Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication | SGD:S000000218 | GRX7 |

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[+]  WN66_00268 | gene269 | WN66_00268 | protein_coding | Gene | YBR015C~MNN2,CRV4,LDB8,TTP1~Verified | Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment | SGD:S000000219 | MNN2 |

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[+]  WN66_00269 | gene270 | WN66_00269 | protein_coding | Gene | YBR016W~Verified | | | |

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[+]  WN66_00270 | gene271 | WN66_00270 | protein_coding | Gene | YBR017C~KAP104~Verified | Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis | SGD:S000000221 | KAP104 |

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[+]  WN66_00271 | gene272 | WN66_00271 | protein_coding | Gene | YBR018C~GAL7~Verified | Galactose-1-phosphate uridyl transferase; synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism; human homolog UGP2 can complement yeast null mutant | SGD:S000000222 | GAL7 |

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[+]  WN66_00272 | gene273 | WN66_00272 | protein_coding | Gene | YBR019C~GAL10~Verified | UDP-glucose-4-epimerase; catalyzes interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; human homolog GALE implicated in galactosemia, can complement yeast null mutant | SGD:S000000223 | GAL10 |

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