Feature Listing

[+]  WN66_00273 | gene274 | WN66_00273 | protein_coding | Gene | YBR020W~GAL1~Verified | Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; human homolog GALK2 complements yeast null mutant; GAL1 has a paralog, GAL3, that arose from the whole genome duplication | SGD:S000000224 | GAL1 |

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[+]  WN66_00274 | gene275 | WN66_00274 | protein_coding | Gene | YBR021W~FUR4~Verified | Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation | SGD:S000000225 | FUR4 |

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[+]  WN66_00275 | gene276 | WN66_00275 | protein_coding | Gene | YBR022W~POA1~Verified | Phosphatase that is highly specific for ADP-ribose 1''-phosphate; a tRNA splicing metabolite; may have a role in regulation of tRNA splicing | SGD:S000000226 | POA1 |

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[+]  WN66_00276 | gene277 | WN66_00276 | protein_coding | Gene | YBR023C~CHS3,CAL1,CSD2,DIT101,KTI2~Verified | Chitin synthase III; catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan; contains overlapping di-leucine and di-acidic signals that mediate, respectively, intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3 complex for its intracellular retention | SGD:S000000227 | CHS3 |

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[+]  WN66_00277 | gene278 | WN66_00277 | protein_coding | Gene | YBR024W~SCO2~Verified | Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication | SGD:S000000228 | SCO2 |

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[+]  WN66_00278 | gene279 | WN66_00278 | protein_coding | Gene | YBR025C~OLA1~Verified | P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress | SGD:S000000229 | OLA1 |

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[+]  WN66_00279 | gene280 | WN66_00279 | protein_coding | Gene | YBR026C~ETR1,MRF1,MRF1'~Verified | 2-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to mitochondria, where it has a probable role in fatty acid synthesis; human MECR functionally complements the respiratory growth defect of the null mutant | SGD:S000000230 | ETR1 |

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[+]  WN66_00280 | gene281 | WN66_00280 | protein_coding | Gene | YBR028C~Verified | AGC kinase; phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner; directly phosphorylated by TORC1; phosphorylates ribosomal protein Rps6a/b (S6), in a TORC-dependent manner; undergoes autophosphorylation | SGD:S000000232 | YPK3 |

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[+]  WN66_00281 | gene282 | WN66_00281 | protein_coding | Gene | YBR029C~CDS1,CDG1~Verified | Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; human homolog CDS1 can complement yeast cds1 null mutant | SGD:S000000233 | CDS1 |

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[+]  WN66_00282 | gene283 | WN66_00282 | protein_coding | Gene | YBR030W~RKM3~Verified | Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; relocalizes to the cytosol in response to hypoxia | SGD:S000000234 | RKM3 |

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[+]  WN66_00283 | gene284 | WN66_00283 | protein_coding | Gene | YBR031W~RPL4A~Verified | Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication | SGD:S000000235 | RPL4A |

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[+]  WN66_00284 | gene285 | WN66_00284 | pseudogene | Gene | YBR032W~Dubious | Putative protein of unknown function; conserved among S. cerevisiae strains; YBR032W is not an essential gene | SGD:S000000236 | | true

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[+]  WN66_00285 | gene286 | WN66_00285 | protein_coding | Gene | YBR033W~EDS1~Uncharacterized | Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication | SGD:S000000237 | EDS1 |

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[+]  WN66_00286 | gene287 | WN66_00286 | protein_coding | Gene | YBR034C~HMT1,HCP1,ODP1,RMT1~Verified | Nuclear SAM-dependent mono- and asymmetric methyltransferase; modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p, ribosomal protein Rps2p, and histones H3 and H4; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region | SGD:S000000238 | HMT1 |

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[+]  WN66_00287 | gene288 | WN66_00287 | protein_coding | Gene | YBR035C~PDX3~Verified | Pyridoxine (pyridoxamine) phosphate oxidase; has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism | SGD:S000000239 | PDX3 |

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[+]  WN66_00288 | gene289 | WN66_00288 | snoRNA | Gene | | | | |

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[+]  WN66_00289 | gene290 | WN66_00289 | ncRNA | Gene | | | | |

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[+]  WN66_00290 | gene291 | WN66_00290 | protein_coding | Gene | YBR036C~CSG2,CLS2~Verified | Endoplasmic reticulum membrane protein; required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress | SGD:S000000240 | CSG2 |

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[+]  WN66_00291 | gene292 | WN66_00291 | protein_coding | Gene | YBR037C~SCO1,PET161~Verified | Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication | SGD:S000000241 | SCO1 |

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[+]  WN66_00292 | gene293 | WN66_00292 | protein_coding | Gene | YBR038W~CHS2~Verified | Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis | SGD:S000000242 | CHS2 |

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[+]  WN66_00293 | gene294 | WN66_00293 | protein_coding | Gene | YBR039W~ATP3~Verified | Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis | SGD:S000000243 | ATP3 |

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[+]  WN66_00294 | gene295 | WN66_00294 | protein_coding | Gene | YBR040W~Verified | | | |

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[+]  WN66_00295 | gene296 | WN66_00295 | protein_coding | Gene | YBR041W~FAT1~Verified | Very long chain fatty acyl-CoA synthetase and fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids | SGD:S000000245 | FAT1 |

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[+]  WN66_00296 | gene297 | WN66_00296 | protein_coding | Gene | YBR042C~CST26,PSI1~Verified | Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication | SGD:S000000246 | CST26 |

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[+]  WN66_00297 | gene298 | WN66_00297 | protein_coding | Gene | YBR043C~QDR3,AQR2~Verified | Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; involved in spore wall asembly; sequence similarity to DTR1 and QDR1, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin | SGD:S000000247 | QDR3 |

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[+]  WN66_00298 | gene299 | WN66_00298 | protein_coding | Gene | YBR044C~TCM62~Verified | Protein involved in assembly of the succinate dehydrogenase complex; mitochondrial; putative chaperone | SGD:S000000248 | TCM62 |

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[+]  WN66_00299 | gene300 | WN66_00299 | tRNA | Gene | tV(UAC)B | | | |

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[+]  WN66_07004 | gene301 | WN66_07004 | protein_coding | Gene | potentially novel~GTK30B01610 | | | |

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[+]  WN66_07003 | gene302 | WN66_07003 | protein_coding | Gene | potentially novel~GTK30B01600 | | | |

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[+]  WN66_07002 | gene303 | WN66_07002 | protein_coding | Gene | potentially novel~GTK30B01590 | | | |

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[+]  WN66_07005 | gene304 | WN66_07005 | protein_coding | Gene | potentially novel~GTK30B01620 | | | |

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[+]  WN66_00300 | gene305 | WN66_00300 | protein_coding | Gene | YBR045C~GIP1~Verified | Meiosis-specific regulatory subunit of the Glc7p protein phosphatase; regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p | SGD:S000000249 | GIP1 |

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[+]  WN66_00301 | gene306 | WN66_00301 | protein_coding | Gene | YBR046C~ZTA1~Verified | NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin | SGD:S000000250 | ZTA1 |

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[+]  WN66_00302 | gene307 | WN66_00302 | protein_coding | Gene | YBR047W~FMP23~Uncharacterized | Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies | SGD:S000000251 | FMP23 |

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[+]  WN66_00303 | gene308 | WN66_00303 | protein_coding | Gene | YBR048W~RPS11B~Verified | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication | SGD:S000000252 | RPS11B |

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[+]  WN66_00304 | gene309 | WN66_00304 | protein_coding | Gene | YBR049C~REB1,GRF2~Verified | RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; Reb1p bound to DNA acts to block RNA polymerase II readthrough transcription | SGD:S000000253 | REB1 |

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[+]  WN66_00305 | gene310 | WN66_00305 | protein_coding | Gene | YBR050C~REG2~Verified | Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease; REG2 has a paralog, REG1, that arose from the whole genome duplication | SGD:S000000254 | REG2 |

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[+]  WN66_00306 | gene311 | WN66_00306 | protein_coding | Gene | YBR051W~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase | SGD:S000000255 | |

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[+]  WN66_00307 | gene312 | WN66_00307 | protein_coding | Gene | YBR052C~RFS1~Verified | Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication | SGD:S000000256 | RFS1 |

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[+]  WN66_00308 | gene313 | WN66_00308 | protein_coding | Gene | YBR053C~Uncharacterized | Putative protein of unknown function; induced by cell wall perturbation | SGD:S000000257 | |

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[+]  WN66_00309 | gene314 | WN66_00309 | protein_coding | Gene | YBR054W~YRO2~Verified | Protein with a putative role in response to acid stress; null mutant is sensitive to acetic acid; transcription is regulated by Haa1p and induced in the presence of acetic acid; protein observed in plasma membrane foci in the presence of acetic acid; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies | SGD:S000000258 | YRO2 |

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[+]  WN66_00310 | gene315 | WN66_00310 | protein_coding | Gene | YBR055C~PRP6,RNA6,TSM7269~Verified | Splicing factor; component of the U4/U6-U5 snRNP complex | SGD:S000000259 | PRP6 |

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[+]  WN66_00311 | gene316 | WN66_00311 | tRNA | Gene | tL(UAA)B2 | | | |

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[+]  WN66_00312 | gene317 | WN66_00312 | protein_coding | Gene | YBR056W~Verified | Putative glycoside hydrolase of the mitochondrial intermembrane space | SGD:S000000260 | |

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[+]  WN66_00313 | gene318 | WN66_00313 | tRNA | Gene | tQ(UUG)B | | | |

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[+]  WN66_00314 | gene319 | WN66_00314 | protein_coding | Gene | YBR056W-A~Uncharacterized | Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps dubious ORF YBR056C-B; YBR056W-A has a paralog, YDR034W-B, that arose from the whole genome duplication | SGD:S000028736 | |

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[+]  WN66_00315 | gene320 | WN66_00315 | protein_coding | Gene | YBR056C-B~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the dubious ORF YBR056W-A | SGD:S000087087 | |

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[+]  WN66_00316 | gene321 | WN66_00316 | protein_coding | Gene | YBR057C~MUM2,SPOT8~Verified | Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p, which is a component of the origin recognition complex | SGD:S000000261 | MUM2 |

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[+]  WN66_00317 | gene322 | WN66_00317 | protein_coding | Gene | YBR058C~UBP14,GID6~Verified | Ubiquitin-specific protease; specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T | SGD:S000000262 | UBP14 |

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[+]  WN66_00318 | gene323 | WN66_00318 | protein_coding | Gene | YBR058C-A~TSC3~Verified | Protein that stimulates the activity of serine palmitoyltransferase; involved in sphingolipid biosynthesis; Lcb1p and Lcb2p are the two components of serine palmitoyltransferase | SGD:S000007521 | TSC3 |

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