Feature Listing

[+]  WN66_00369 | gene374 | WN66_00369 | protein_coding | Gene | YBR104W~YMC2~Verified | Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication | SGD:S000000308 | YMC2 |

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[+]  WN66_00370 | gene375 | WN66_00370 | protein_coding | Gene | YBR105C~VID24,GID4~Verified | GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles | SGD:S000000309 | VID24 |

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[+]  WN66_00371 | gene376 | WN66_00371 | protein_coding | Gene | YBR106W~PHO88~Verified | Probable membrane protein; involved in phosphate transport; role in the maturation of secretory proteins; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations | SGD:S000000310 | PHO88 |

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[+]  WN66_00372 | gene377 | WN66_00372 | protein_coding | Gene | YBR107C~IML3,MCM19~Verified | Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; forms a stable complex with Chl4p; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1 | SGD:S000000311 | IML3 |

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[+]  WN66_00373 | gene378 | WN66_00373 | protein_coding | Gene | YBR108W~AIM3~Verified | Protein that inhibits barbed-end actin filament elongation; interacts with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss | SGD:S000000312 | AIM3 |

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[+]  WN66_00374 | gene379 | WN66_00374 | protein_coding | Gene | YBR109C~CMD1,CaM~Verified | Calmodulin; Ca2+ binding protein that regulates Ca2+ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca2+ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin; binds to the Hog1p MAPK in response to hyperosmotic stress; potentiates membrane tubulation and constriction mediated by the Rvs161p-Rvs167p complex; human CALM1 or CALM2 functionally complement repression induced inviability | SGD:S000000313 | CMD1 |

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[+]  WN66_00375 | gene380 | WN66_00375 | protein_coding | Gene | YBR109W-A~Dubious | Putative protein of unknown function; questionable ORF from MIPS | SGD:S000028737 | |

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[+]  WN66_00376 | gene381 | WN66_00376 | protein_coding | Gene | YBR110W~ALG1~Verified | Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant | SGD:S000000314 | ALG1 |

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[+]  WN66_00377 | gene382 | WN66_00377 | protein_coding | Gene | YBR111C~YSA1,RMA2~Verified | Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate | SGD:S000000315 | YSA1 |

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[+]  WN66_00378 | gene383 | WN66_00378 | protein_coding | Gene | YBR111W-A~SUS1~Verified | Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP | SGD:S000028510 | SUS1 |

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[+]  WN66_00379 | gene384 | WN66_00379 | protein_coding | Gene | YBR112C~CYC8,CRT8,SSN6~Verified | General transcriptional co-repressor; acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+] | SGD:S000000316 | CYC8 |

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[+]  WN66_00380 | gene385 | WN66_00380 | protein_coding | Gene | YBR113W~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8 | SGD:S000000317 | |

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[+]  WN66_00381 | gene386 | WN66_00381 | protein_coding | Gene | YBR114W~RAD16,PSO5~Verified | Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex | SGD:S000000318 | RAD16 |

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[+]  WN66_00382 | gene387 | WN66_00382 | protein_coding | Gene | YBR115C~LYS2~Verified | Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p | SGD:S000000319 | LYS2 |

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[+]  WN66_00383 | gene388 | WN66_00383 | protein_coding | Gene | YBR117C~TKL2~Verified | Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL2 has a paralog, TKL1, that arose from the whole genome duplication | SGD:S000000321 | TKL2 |

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[+]  WN66_00384 | gene389 | WN66_00384 | protein_coding | Gene | YBR118W~TEF2,EF-1%20alpha~Verified | Translational elongation factor EF-1 alpha; in the GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; associates with vacuolar Rho1p GTPase; TEF2-RFP levels increase during replicative aging; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication | SGD:S000000322 | TEF2 |

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[+]  WN66_00385 | gene390 | WN66_00385 | protein_coding | Gene | YBR119W~MUD1~Verified | U1 snRNP A protein; homolog of human U1-A; involved in nuclear mRNA splicing | SGD:S000000323 | MUD1 |

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[+]  WN66_00386 | gene391 | WN66_00386 | protein_coding | Gene | YBR120C~CBP6~Verified | Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation | SGD:S000000324 | CBP6 |

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[+]  WN66_00387 | gene392 | WN66_00387 | protein_coding | Gene | YBR121C~GRS1~Verified | Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication; human homolog GARS implicated in Charcot-Marie-Tooth disease, can complement yeast null mutant | SGD:S000000325 | GRS1 |

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[+]  WN66_00388 | gene393 | WN66_00388 | protein_coding | Gene | YBR122C~MRPL36~Verified | Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region | SGD:S000000326 | MRPL36 |

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[+]  WN66_00389 | gene394 | WN66_00389 | protein_coding | Gene | YBR123C~TFC1~Verified | Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63 | SGD:S000000327 | TFC1 |

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[+]  WN66_00390 | gene395 | WN66_00390 | protein_coding | Gene | YBR124W~Dubious | Putative protein of unknown function | SGD:S000000328 | |

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[+]  WN66_00391 | gene396 | WN66_00391 | protein_coding | Gene | YBR125C~PTC4,GCT1~Verified | Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity | SGD:S000000329 | PTC4 |

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[+]  WN66_00392 | gene397 | WN66_00392 | protein_coding | Gene | YBR126C~TPS1,BYP1,CIF1,FDP1,GGS1,GLC6,TSS1~Verified | Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose, which is critically important for survival of long-term desiccation; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid | SGD:S000000330 | TPS1 |

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[+]  WN66_00393 | gene398 | WN66_00393 | protein_coding | Gene | YBR126W-A~Uncharacterized | Putative protein of unknown function; identified by gene-trapping, microarray analysis, and genome-wide homology searches; mRNA identified as translated by ribosome profiling data; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; partially overlaps the dubious ORF YBR126W-B | SGD:S000028600 | MEO1 |

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[+]  WN66_00394 | gene399 | WN66_00394 | protein_coding | Gene | YBR126W-B~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-A; identified by SAGE | SGD:S000028738 | |

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[+]  WN66_00395 | gene400 | WN66_00395 | protein_coding | Gene | YBR127C~VMA2,ATPSV,VAT2~Verified | Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase; electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm; protein abundance increases in response to DNA replication stress; human homolog ATP6V1B1, implicated in autosomal-recessive distal renal tubular acidosis (RTA) with sensorineural deafness, complements yeast null mutant | SGD:S000000331 | VMA2 |

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[+]  WN66_00396 | gene401 | WN66_00396 | protein_coding | Gene | YBR128C~ATG14,APG14,CVT12~Verified | Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I; Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor; other members are Vps34, Vps15, and Vps30p | SGD:S000000332 | ATG14 |

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[+]  WN66_00397 | gene402 | WN66_00397 | protein_coding | Gene | YBR129C~OPY1~Verified | Protein of unknown function; overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies | SGD:S000000333 | OPY1 |

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[+]  WN66_00398 | gene403 | WN66_00398 | protein_coding | Gene | YBR130C~SHE3~Verified | Protein adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance | SGD:S000000334 | SHE3 |

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[+]  WN66_00399 | gene404 | WN66_00399 | protein_coding | Gene | YBR131W~CCZ1,CVT16~Verified | Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex, which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; involved in localizing Ypt7p to the vacuolar membrane; required for macroautophagy, the CVT pathway and mitophagy | SGD:S000000335 | CCZ1 |

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[+]  WN66_00400 | gene405 | WN66_00400 | protein_coding | Gene | YBR131C-A~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR131W; identified by gene-trapping, microarray analysis, and genome-wide homology searches | SGD:S000028601 | |

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[+]  WN66_00401 | gene406 | WN66_00401 | protein_coding | Gene | YBR132C~AGP2~Verified | Plasma membrane regulator of polyamine and carnitine transport; has similarity to transporters but lacks transport activity; may act as a sensor that transduces environmental signals; has a positive or negative regulatory effect on transcription of many transporter genes | SGD:S000000336 | AGP2 |

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[+]  WN66_00402 | gene407 | WN66_00402 | protein_coding | Gene | YBR133C~HSL7~Verified | Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent localization to the bud neck in budded cells and periodic Hsl1p-dependent phosphorylation; required with Hsl1p, and Elm1p for the mother-bud neck recruitment, phosphorylation, and degradation of Swe1p; interacts directly with Swe1p; relocalizes away from bud neck upon DNA replication stress; human homolog PRMT5 can complement yeast hsl7 mutant | SGD:S000000337 | HSL7 |

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[+]  WN66_00403 | gene408 | WN66_00403 | protein_coding | Gene | YBR135W~Verified | | | |

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[+]  WN66_00404 | gene409 | WN66_00404 | protein_coding | Gene | YBR136W~MEC1,ESR1,SAD3~Verified | Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses to damaged or unreplicated DNA; facilitates replication fork progression and regulates P-body formation under replication stress; promotes interhomolog recombination by phosphorylating Hop1p; associates with shortened, dysfunctional telomeres | SGD:S000000340 | MEC1 |

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[+]  WN66_00405 | gene410 | WN66_00405 | protein_coding | Gene | YBR137W~Verified | Protein with a role in ER delivery of tail-anchored membrane proteins; interacts with Sgt2p; binds to the TRC complex, which inserts proteins into the ER membrane; interacts with Msn5p karyopherin; YBR137W is not an essential gene | SGD:S000000341 | |

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[+]  WN66_00406 | gene411 | WN66_00406 | protein_coding | Gene | YBR138C~HDR1~Uncharacterized | Cytoplasmic protein of unknown function; APCC(Cdh1) substrate; potentially phosphorylated by Cdc28p; YBR138C is not an essential gene | SGD:S000000342 | |

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[+]  WN66_00407 | gene412 | WN66_00407 | protein_coding | Gene | YBR139W~Verified | Putative serine type carboxypeptidase; role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner | SGD:S000000343 | |

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[+]  WN66_00408 | gene413 | WN66_00408 | protein_coding | Gene | YBR140C~IRA1,GLC1,PPD1~Verified | GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis | SGD:S000000344 | IRA1 |

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[+]  WN66_00409 | gene414 | WN66_00409 | protein_coding | Gene | YBR141C~Verified | Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 2142; belongs to Rossmann fold superfamily; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene | SGD:S000000345 | BMT2 |

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[+]  WN66_00410 | gene415 | WN66_00410 | protein_coding | Gene | YBR141W-A~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YBR141C; identified by gene-trapping, microarray analysis, and genome-wide homology searching | SGD:S000028602 | |

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[+]  WN66_00411 | gene416 | WN66_00411 | protein_coding | Gene | YBR142W~MAK5~Verified | Essential nucleolar protein; putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits | SGD:S000000346 | MAK5 |

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[+]  WN66_00412 | gene417 | WN66_00412 | protein_coding | Gene | YBR143C~SUP45,SAL4,SUP1,SUP47~Verified | Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p | SGD:S000000347 | SUP45 |

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[+]  WN66_00413 | gene418 | WN66_00413 | protein_coding | Gene | YBR144C~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene | SGD:S000000348 | |

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[+]  WN66_00414 | gene419 | WN66_00414 | protein_coding | Gene | YBR145W~ADH5~Verified | Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication | SGD:S000000349 | ADH5 |

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[+]  WN66_00415 | gene420 | WN66_00415 | protein_coding | Gene | YBR146W~MRPS9~Verified | Mitochondrial ribosomal protein of the small subunit | SGD:S000000350 | MRPS9 |

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[+]  WN66_00416 | gene421 | WN66_00416 | protein_coding | Gene | YBR147W~RTC2,RRT11~Verified | Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication | SGD:S000000351 | RTC2 |

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[+]  WN66_00417 | gene422 | WN66_00417 | protein_coding | Gene | YBR148W~Verified | | | |

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[+]  WN66_00418 | gene423 | WN66_00418 | protein_coding | Gene | YBR149W~ARA1~Verified | NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product | SGD:S000000353 | ARA1 |

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