Feature Listing

[+]  WN66_00419 | gene424 | WN66_00419 | protein_coding | Gene | YBR150C~Verified | | | |

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[+]  WN66_00420 | gene425 | WN66_00420 | protein_coding | Gene | YBR151W~APD1~Verified | Protein of unknown function; required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus | SGD:S000000355 | APD1 |

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[+]  WN66_00421 | gene426 | WN66_00421 | protein_coding | Gene | YBR152W~SPP381~Verified | mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; relocalizes to the cytosol in response to hypoxia | SGD:S000000356 | SPP381 |

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[+]  WN66_00422 | gene427 | WN66_00422 | protein_coding | Gene | YBR153W~RIB7~Verified | Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway | SGD:S000000357 | RIB7 |

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[+]  WN66_00423 | gene428 | WN66_00423 | protein_coding | Gene | YBR154C~RPB5~Verified | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation | SGD:S000000358 | RPB5 |

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[+]  WN66_00424 | gene429 | WN66_00424 | protein_coding | Gene | YBR155W~CNS1~Verified | TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70); stimulates ATPase activity of Ssa1p; ts mutants reduce Hsp82p function, overexpression suppresses phenotypes of HSP82 ts allele and cpr7 deletion; human homolog TTC4 complements yeast cns1 mutant | SGD:S000000359 | CNS1 |

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[+]  WN66_00425 | gene430 | WN66_00425 | protein_coding | Gene | YBR156C~SLI15~Verified | Subunit of the conserved chromosomal passenger complex (CPC); complex regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; other complex members are Ipl1p, Bir1p, and Nbl1p | SGD:S000000360 | SLI15 |

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[+]  WN66_00426 | gene431 | WN66_00426 | protein_coding | Gene | YBR157C~ICS2~Verified | Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | SGD:S000000361 | ICS2 |

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[+]  WN66_00427 | gene432 | WN66_00427 | protein_coding | Gene | YBR158W~AMN1,CST13,ICS4~Verified | Protein required for daughter cell separation; multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) | SGD:S000000362 | AMN1 |

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[+]  WN66_00428 | gene433 | WN66_00428 | protein_coding | Gene | YBR159W~IFA38~Verified | Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides | SGD:S000000363 | IFA38 |

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[+]  WN66_00429 | gene434 | WN66_00429 | protein_coding | Gene | YBR160W~CDC28,CDK1,HSL5,SRM5~Verified | Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant | SGD:S000000364 | CDC28 |

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[+]  WN66_00430 | gene435 | WN66_00430 | pseudogene | Gene | YBR161W~CSH1~Verified | Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication | SGD:S000000365 | CSH1 | true

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[+]  WN66_00431 | gene436 | WN66_00431 | protein_coding | Gene | YBR162C~TOS1~Verified | Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C | SGD:S000000366 | TOS1 |

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[+]  WN66_00432 | gene437 | WN66_00432 | protein_coding | Gene | YBR162W-A~YSY6~Verified | Protein of unknown function; expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion | SGD:S000002158 | YSY6 |

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[+]  WN66_00433 | gene438 | WN66_00433 | protein_coding | Gene | YBR163W~EXO5,DEM1~Verified | Mitochondrial 5'-3' exonuclease and sliding exonuclease; required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 | SGD:S000000367 | EXO5 |

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[+]  WN66_00434 | gene439 | WN66_00434 | protein_coding | Gene | YBR164C~ARL1,DLP2~Verified | Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; G protein of the Ras superfamily, similar to ADP-ribosylation factor | SGD:S000000368 | ARL1 |

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[+]  WN66_00435 | gene440 | WN66_00435 | protein_coding | Gene | YBR165W~UBS1~Verified | Ubiquitin-conjugating enzyme suppressor that regulates Cdc34p; functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity | SGD:S000000369 | UBS1 |

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[+]  WN66_00436 | gene441 | WN66_00436 | protein_coding | Gene | YBR166C~TYR1~Verified | Prephenate dehydrogenase involved in tyrosine biosynthesis; expression is dependent on phenylalanine levels | SGD:S000000370 | TYR1 |

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[+]  WN66_00437 | gene442 | WN66_00437 | protein_coding | Gene | YBR167C~POP7,RPP2~Verified | Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA | SGD:S000000371 | POP7 |

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[+]  WN66_00438 | gene443 | WN66_00438 | protein_coding | Gene | YBR168W~PEX32~Verified | Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p | SGD:S000000372 | PEX32 |

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[+]  WN66_00439 | gene444 | WN66_00439 | protein_coding | Gene | YBR169C~SSE2~Verified | Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication | SGD:S000000373 | SSE2 |

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[+]  WN66_00440 | gene445 | WN66_00440 | protein_coding | Gene | YBR170C~NPL4,HRD4~Verified | Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) | SGD:S000000374 | NPL4 |

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[+]  WN66_00441 | gene446 | WN66_00441 | protein_coding | Gene | YBR171W~SEC66,HSS1,SEC71~Verified | Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec63p, Sec62p, and Sec72p | SGD:S000000375 | SEC66 |

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[+]  WN66_00442 | gene447 | WN66_00442 | protein_coding | Gene | YBR172C~SMY2~Verified | GYF domain protein; involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication | SGD:S000000376 | SMY2 |

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[+]  WN66_00443 | gene448 | WN66_00443 | protein_coding | Gene | YBR173C~UMP1,RNS2~Verified | Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly | SGD:S000000377 | UMP1 |

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[+]  WN66_00444 | gene449 | WN66_00444 | protein_coding | Gene | YBR174C~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective | SGD:S000000378 | |

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[+]  WN66_00445 | gene450 | WN66_00445 | protein_coding | Gene | YBR175W~SWD3,CPS30,SAF35~Verified | Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 | SGD:S000000379 | SWD3 |

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[+]  WN66_00446 | gene451 | WN66_00446 | protein_coding | Gene | YBR176W~ECM31~Verified | Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate | SGD:S000000380 | ECM31 |

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[+]  WN66_00447 | gene452 | WN66_00447 | protein_coding | Gene | YBR177C~EHT1~Verified | Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication | SGD:S000000381 | EHT1 |

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[+]  WN66_00448 | gene453 | WN66_00448 | protein_coding | Gene | YBR178W~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C | SGD:S000000382 | |

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[+]  WN66_00449 | gene454 | WN66_00449 | protein_coding | Gene | YBR179C~FZO1~Verified | Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system | SGD:S000000383 | FZO1 |

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[+]  WN66_00450 | gene455 | WN66_00450 | protein_coding | Gene | YBR180W~DTR1~Verified | Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation | SGD:S000000384 | DTR1 |

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[+]  WN66_00451 | gene456 | WN66_00451 | protein_coding | Gene | YBR181C~RPS6B,LPG18,RPS101,RPS102~Verified | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication | SGD:S000000385 | RPS6B |

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[+]  WN66_00452 | gene457 | WN66_00452 | protein_coding | Gene | YBR182C~SMP1~Verified | MADS-box transcription factor involved in osmotic stress response; SMP1 has a paralog, RLM1, that arose from the whole genome duplication | SGD:S000000386 | SMP1 |

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[+]  WN66_00453 | gene458 | WN66_00453 | protein_coding | Gene | YBR182C-A~Uncharacterized | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching | SGD:S000028603 | |

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[+]  WN66_00454 | gene459 | WN66_00454 | protein_coding | Gene | YBR183W~YPC1~Verified | Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication | SGD:S000000387 | YPC1 |

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[+]  WN66_00455 | gene460 | WN66_00455 | protein_coding | Gene | YBR184W~Uncharacterized | Putative protein of unknown function; YBR184W is not an essential gene | SGD:S000000388 | |

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[+]  WN66_00456 | gene461 | WN66_00456 | protein_coding | Gene | YBR185C~MBA1~Verified | Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane | SGD:S000000389 | MBA1 |

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[+]  WN66_00457 | gene462 | WN66_00457 | protein_coding | Gene | YBR186W~PCH2~Verified | Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in rDNA; required for meiotic double-stranded break formation | SGD:S000000390 | PCH2 |

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[+]  WN66_00458 | gene463 | WN66_00458 | protein_coding | Gene | YBR187W~GDT1~Verified | Calcium transporter localized to the cis- and medial-Golgi apparatus; required for protein glycosylation; GFP-fusion protein localizes to the vacuole; TMEM165, a human gene which causes Congenital Disorders of Glycosylation is orthologous and functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression reduced in a gcr1 null mutant | SGD:S000000391 | GDT1 |

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[+]  WN66_00459 | gene464 | WN66_00459 | protein_coding | Gene | YBR188C~NTC20~Verified | Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs | SGD:S000000392 | NTC20 |

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[+]  WN66_00460 | gene465 | WN66_00460 | protein_coding | Gene | YBR189W~RPS9B,RPS13A,SUP46~Verified | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication | SGD:S000000393 | RPS9B |

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[+]  WN66_00461 | gene466 | WN66_00461 | protein_coding | Gene | YBR191W~RPL21A,URP1~Verified | Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication | SGD:S000000395 | RPL21A |

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[+]  WN66_00462 | gene467 | WN66_00462 | protein_coding | Gene | YBR191W-A~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | SGD:S000007594 | |

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[+]  WN66_00463 | gene468 | WN66_00463 | protein_coding | Gene | YBR192W~RIM2,PYT1~Verified | Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family | SGD:S000000396 | RIM2 |

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[+]  WN66_00464 | gene469 | WN66_00464 | protein_coding | Gene | YBR193C~MED8~Verified | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation | SGD:S000000397 | MED8 |

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[+]  WN66_00465 | gene470 | WN66_00465 | protein_coding | Gene | YBR194W~AIM4,SOY1~Verified | Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress | SGD:S000000398 | AIM4 |

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[+]  WN66_00466 | gene471 | WN66_00466 | protein_coding | Gene | YBR195C~MSI1,CAC3~Verified | Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase | SGD:S000000399 | MSI1 |

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[+]  WN66_00467 | gene472 | WN66_00467 | protein_coding | Gene | YBR196C~PGI1,CDC30~Verified | Glycolytic enzyme phosphoglucose isomerase; catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation | SGD:S000000400 | PGI1 |

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[+]  WN66_00468 | gene473 | WN66_00468 | protein_coding | Gene | YBR196C-A~Uncharacterized | Putative protein of unknown function; identified by fungal homology and RT-PCR | SGD:S000028534 | |

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