Feature Listing

[+]  WN66_00124 | gene124 | WN66_00124 | pseudogene | Gene | potentially novel~GTK30B00100 | | | | true

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[+]  WN66_00125 | gene125 | WN66_00125 | pseudogene | Gene | potentially novel~GTK30B00110 | | | | true

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[+]  WN66_00126 | gene126 | WN66_00126 | protein_coding | Gene | YBL113W-A~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching | SGD:S000028599 | |

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[+]  WN66_00127 | gene127 | WN66_00127 | protein_coding | Gene | potentially novel~GTK30B00120 | | | |

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[+]  WN66_00128 | gene128 | WN66_00128 | protein_coding | Gene | potentially novel~GTK30B00140 | | | |

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[+]  WN66_00129 | gene129 | WN66_00129 | protein_coding | Gene | potentially novel~GTK30B00150 | | | |

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[+]  WN66_00130 | gene130 | WN66_00130 | protein_coding | Gene | potentially novel~GTK30B00160 | | | |

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[+]  WN66_00131 | gene131 | WN66_00131 | protein_coding | Gene | YBL108C-A~Verified | | | |

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[+]  WN66_00132 | gene132 | WN66_00132 | pseudogene | Gene | YBL108W~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | SGD:S000000204 | | true

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[+]  WN66_00133 | gene133 | WN66_00133 | tRNA | Gene | tL(UAA)B1 | | | |

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[+]  WN66_00134 | gene134 | WN66_00134 | protein_coding | Gene | YBL107C~Verified | Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C) | SGD:S000000203 | MIX23 |

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[+]  WN66_00135 | gene135 | WN66_00135 | protein_coding | Gene | YBL106C~SRO77,SNI2,SOP2~Verified | Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; interacts with SNARE protein Sec9p; homolog of Drosophila lethal giant larvae tumor suppressor; SRO77 has a paralog, SRO7, that arose from the whole genome duplication | SGD:S000000202 | SRO77 |

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[+]  WN66_00136 | gene136 | WN66_00136 | protein_coding | Gene | YBL105C~PKC1,CLY15,HPO2,STT1~Verified | Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) | SGD:S000000201 | PKC1 |

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[+]  WN66_00137 | gene137 | WN66_00137 | protein_coding | Gene | YBL104C~YBL103C-A~Verified | Subunit of SEACAT, a subcomplex of the SEA complex; Sea4p, along with Rtc1p and Mtc5p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; contains an N-terminal beta-propeller fold and a C-terminal RING motif | SGD:S000000200 | SEA4 |

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[+]  WN66_00138 | gene138 | WN66_00138 | protein_coding | Gene | YBL103C~RTG3~Verified | bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways; forms a complex with another bHLH/Zip protein, Rtg1p, to activate the pathways; target of Hog1p | SGD:S000000199 | RTG3 |

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[+]  WN66_00139 | gene139 | WN66_00139 | protein_coding | Gene | YBL102W~SFT2~Verified | Tetra-spanning membrane protein found mostly in the late Golgi; non-essential; can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 | SGD:S000000198 | SFT2 |

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[+]  WN66_00140 | gene140 | WN66_00140 | protein_coding | Gene | YBL101C~ECM21,ART2~Verified | Protein involved in regulating endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements; ECM21 has a paralog, CSR2, that arose from the whole genome duplication | SGD:S000000197 | ECM21 |

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[+]  WN66_00141 | gene141 | WN66_00141 | protein_coding | Gene | YBL100W-C~YBL101W-C~Uncharacterized | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching | SGD:S000028598 | |

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[+]  WN66_07001 | gene142 | WN66_07001 | pseudogene | Gene | potentially novel~GTK30B00250 | | | | true

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[+]  WN66_00142 | gene143 | WN66_00142 | tRNA | Gene | tF(GAA)B | | | |

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[+]  WN66_00143 | gene144 | WN66_00143 | protein_coding | Gene | YBL100C~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1 | SGD:S000000196 | |

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[+]  WN66_00144 | gene145 | WN66_00144 | protein_coding | Gene | YBL099W~ATP1~Verified | Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; N-terminally propionylated in vivo | SGD:S000000195 | ATP1 |

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[+]  WN66_00145 | gene146 | WN66_00145 | protein_coding | Gene | YBL098W~BNA4~Verified | Kynurenine 3-monooxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease | SGD:S000000194 | BNA4 |

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[+]  WN66_00146 | gene147 | WN66_00146 | protein_coding | Gene | YBL097W~BRN1~Verified | Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission | SGD:S000000193 | BRN1 |

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[+]  WN66_00147 | gene148 | WN66_00147 | protein_coding | Gene | YBL096C~Dubious | Non-essential protein of unknown function | SGD:S000000192 | |

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[+]  WN66_00148 | gene149 | WN66_00148 | protein_coding | Gene | YBL095W~Uncharacterized | Protein that associates with mitochondrial ribosome; likely functions in cristae junction formation; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies | SGD:S000000191 | MRX3 |

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[+]  WN66_00149 | gene150 | WN66_00149 | protein_coding | Gene | YBL094C~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W | SGD:S000000190 | |

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[+]  WN66_00150 | gene151 | WN66_00150 | protein_coding | Gene | YBL093C~ROX3,MED19,NUT3,SSN7~Verified | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme | SGD:S000000189 | ROX3 |

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[+]  WN66_00151 | gene152 | WN66_00151 | protein_coding | Gene | YBL092W~RPL32~Verified | Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog | SGD:S000000188 | RPL32 |

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[+]  WN66_00152 | gene153 | WN66_00152 | protein_coding | Gene | YBL091C-A~SCS22~Verified | Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect the ER and plasma membrane (PM); regulates PM PI4P levels by controlling access of the Sac1p phosphatase to its substrate, PI4P; human VAP homolog; similar to D. melanogaster inturned protein; SWAT-GFP and mCherry fusion proteins localize to the cytosol; SCS22 has a paralog, SCS2, that arose from the whole genome duplication | SGD:S000007228 | SCS22 |

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[+]  WN66_00153 | gene154 | WN66_00153 | protein_coding | Gene | YBL091C~MAP2~Verified | Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p | SGD:S000000187 | MAP2 |

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[+]  WN66_00154 | gene155 | WN66_00154 | protein_coding | Gene | YBL090W~MRP21,MRP50~Verified | Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences | SGD:S000000186 | MRP21 |

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[+]  WN66_00155 | gene156 | WN66_00155 | protein_coding | Gene | YBL089W~AVT5~Verified | Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication | SGD:S000000185 | AVT5 |

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[+]  WN66_00156 | gene157 | WN66_00156 | protein_coding | Gene | YBL088C~TEL1~Verified | Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; acts with Red1p and Mec1p to promote interhomolog recombination by phosphorylation of Hop1; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene | SGD:S000000184 | TEL1 |

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[+]  WN66_00157 | gene158 | WN66_00157 | protein_coding | Gene | YBL087C~RPL23A~Verified | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication | SGD:S000000183 | RPL23A |

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[+]  WN66_00158 | gene159 | WN66_00158 | protein_coding | Gene | YBL086C~Uncharacterized | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery | SGD:S000000182 | |

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[+]  WN66_00159 | gene160 | WN66_00159 | protein_coding | Gene | YBL085W~BOI1,BOB1,GIN7~Verified | Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication | SGD:S000000181 | BOI1 |

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[+]  WN66_00160 | gene161 | WN66_00160 | protein_coding | Gene | YBL084C~CDC27,APC3,SNB1~Verified | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition | SGD:S000000180 | CDC27 |

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[+]  WN66_00161 | gene162 | WN66_00161 | protein_coding | Gene | YBL082C~ALG3,RHK1~Verified | Dolichol-P-Man dependent alpha(1-3) mannosyltransferase; involved in synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; G353A missense mutation in human ortholog ALG3 implicated in carbohydrate deficient glycoprotein syndrome type IV, which is characterized by microcephaly, severe epilepsy, minimal psychomotor development, partial deficiency of sialic acids in serum glycoproteins; wild-type human ALG3 can complement yeast alg3 mutant | SGD:S000000178 | ALG3 |

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[+]  WN66_00162 | gene163 | WN66_00162 | protein_coding | Gene | YBL081W~Uncharacterized | | | |

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[+]  WN66_00163 | gene164 | WN66_00163 | protein_coding | Gene | YBL080C~PET112~Verified | Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog | SGD:S000000176 | PET112 |

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[+]  WN66_00164 | gene165 | WN66_00164 | protein_coding | Gene | YBL079W~NUP170,NLE3~Verified | Subunit of inner ring of nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; interacts with genomic regions that contain ribosomal protein and subtelomeric genes, where it functions in nucleosome positioning and as a repressor of transcription; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication | SGD:S000000175 | NUP170 |

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[+]  WN66_00165 | gene166 | WN66_00165 | protein_coding | Gene | YBL078C~ATG8,APG8,AUT7,CVT5~Verified | Component of autophagosomes and Cvt vesicles; regulator of Atg1p, targets it to autophagosomes; binds the Atg1p-Atg13p complex, triggering its vacuolar degradation; unique ubiquitin-like protein whose conjugation target is lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis | SGD:S000000174 | ATG8 |

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[+]  WN66_00166 | gene167 | WN66_00166 | protein_coding | Gene | YBL077W~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C | SGD:S000000173 | |

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[+]  WN66_00167 | gene168 | WN66_00167 | protein_coding | Gene | YBL076C~ILS1~Verified | Cytoplasmic isoleucine-tRNA synthetase; target of the G1-specific inhibitor reveromycin A | SGD:S000000172 | ILS1 |

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[+]  WN66_00168 | gene169 | WN66_00168 | protein_coding | Gene | YBL075C~SSA3,YG106~Verified | ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication | SGD:S000000171 | SSA3 |

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[+]  WN66_00169 | gene170 | WN66_00169 | protein_coding | Gene | YBL074C~AAR2~Verified | Component of the U5 snRNP complex; required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron | SGD:S000000170 | AAR2 |

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[+]  WN66_00170 | gene171 | WN66_00170 | protein_coding | Gene | YBL073W~Dubious | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C | SGD:S000000169 | |

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[+]  WN66_00171 | gene172 | WN66_00171 | snoRNA | Gene | | | | |

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[+]  WN66_00172 | gene173 | WN66_00172 | protein_coding | Gene | YBL072C~RPS8A~Verified | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication | SGD:S000000168 | RPS8A |

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