Feature Listing

[+]  | gene1671 | WN66_01649 | protein_coding | Gene | YEL063C~CAN1~Verified | SGD:S000000789 | Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication | CAN1 | | WN66_01649

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[+]  | gene5297 | WN66_05213 | protein_coding | Gene | YNL321W~VNX1~Verified | SGD:S000005265 | Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate | VNX1 | | WN66_05213

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[+]  | gene3809 | WN66_03758 | protein_coding | Gene | YKL216W~URA1~Verified | SGD:S000001699 | Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid | URA1 | | WN66_03758

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[+]  | gene136 | WN66_00136 | protein_coding | Gene | YBL105C~PKC1,CLY15,HPO2,STT1~Verified | SGD:S000000201 | Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) | PKC1 | | WN66_00136

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[+]  | gene6933 | WN66_06785 | tRNA | Gene | tRNAGlu | | | | | WN66_06785

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[+]  | gene18 | WN66_00019 | protein_coding | Gene | YAL054C~ACS1,FUN44~Verified | SGD:S000000050 | Acetyl-coA synthetase isoform; along with Acs2p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions | ACS1 | | WN66_00019

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[+]  | gene2802 | WN66_02761 | protein_coding | Gene | YHL033C~RPL8A,MAK7~Verified | SGD:S000001025 | Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; L8 binds to Domain I of 25S and 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication | RPL8A | | WN66_02761

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[+]  | gene6354 | WN66_06265 | protein_coding | Gene | YPL264C~Uncharacterized | SGD:S000006185 | Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene | | | WN66_06265

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[+]  | gene5298 | WN66_05214 | protein_coding | Gene | YNL320W~Uncharacterized | SGD:S000005264 | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies | | | WN66_05214

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[+]  | gene4766 | WN66_04684 | protein_coding | Gene | YML117W~NAB6~Verified | SGD:S000004585 | Putative RNA-binding protein; associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP | NAB6 | | WN66_04684

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[+]  STL71 | gene3386 | STL71 | protein_coding | Gene | potentially novel~GTK30J00240 | | | | | WN66_03340

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[+]  | gene800 | WN66_00791 | protein_coding | Gene | YDL240W~LRG1~Verified | SGD:S000002399 | GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 (LIM) domains | LRG1 | | WN66_00791

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[+]  | gene5738 | WN66_05650 | protein_coding | Gene | YOL152W~FRE7~Verified | SGD:S000005512 | Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels | FRE7 | | WN66_05650

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[+]  CSS73 | gene3120 | CSS73 | protein_coding | Gene | potentially novel~GTK30I00220 | | | | | WN66_07044

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[+]  | gene5299 | WN66_05215 | protein_coding | Gene | YNL319W~Dubious | SGD:S000005263 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HXT14 | | | WN66_05215

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[+]  | gene2011 | WN66_01985 | protein_coding | Gene | YFL052W~Verified | SGD:S000001842 | Zinc cluster transcription factor that regulates respiratory growth; binds to promoters of genes involved in respiration, gluconeogenesis, and the glyoxylate shunt; required for normal carbon source utilization and stress response | ZNF1 | | WN66_01985

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[+]  | gene1672 | WN66_01650 | protein_coding | Gene | YEL062W~NPR2~Verified | SGD:S000000788 | Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the vacuole; Npr2p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and resulting in inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; homolog of human tumor suppressor NPRL2 | NPR2 | | WN66_01650

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[+]  | gene2165 | WN66_02134 | protein_coding | Gene | YGL251C~HFM1,MER3~Verified | SGD:S000003220 | Meiosis specific DNA helicase; involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity | HFM1 | | WN66_02134

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[+]  | gene5300 | WN66_05216 | protein_coding | Gene | YNL318C~HXT14~Verified | SGD:S000005262 | Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies | HXT14 | | WN66_05216

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[+]  | gene2803 | WN66_02762 | protein_coding | Gene | YHL032C~GUT1~Verified | SGD:S000001024 | Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p | GUT1 | | WN66_02762

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[+]  | gene6355 | WN66_06266 | protein_coding | Gene | YPL263C~KEL3~Verified | SGD:S000006184 | Cytoplasmic protein of unknown function | KEL3 | | WN66_06266

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[+]  ADH8 | gene3387 | ADH8 | protein_coding | Gene | potentially novel~GTK30J00250 | | | | | WN66_03341

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[+]  | gene4767 | WN66_04685 | protein_coding | Gene | YML116W~ATR1,SNQ1~Verified | SGD:S000004584 | Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress | ATR1 | | WN66_04685

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[+]  | gene6937 | WN66_06787 | protein_coding | Gene | Q0110~BI2~Verified | | | | | WN66_06787

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[+]  | gene612 | WN66_00606 | protein_coding | Gene | YCL054W~SPB1~Verified | SGD:S000000559 | AdoMet-dependent methyltransferase; involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants | SPB1 | | WN66_00606

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[+]  | gene5739 | WN66_05651 | protein_coding | Gene | YOL151W~GRE2~Verified | SGD:S000005511 | 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase | GRE2 | | WN66_05651

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[+]  | gene2166 | WN66_02135 | protein_coding | Gene | YGL250W~RMR1~Verified | SGD:S000003219 | Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus | RMR1 | | WN66_02135

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[+]  | gene19 | WN66_00020 | protein_coding | Gene | YAL053W~FLC2,HUF2~Verified | SGD:S000000049 | Putative calcium channel involved in calcium release under hypotonic stress; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication | FLC2 | | WN66_00020

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[+]  | gene5740 | WN66_05652 | protein_coding | Gene | YOL150C~Dubious | SGD:S000005510 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | | WN66_05652

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[+]  | gene137 | WN66_00137 | protein_coding | Gene | YBL104C~YBL103C-A~Verified | SGD:S000000200 | Subunit of SEACAT, a subcomplex of the SEA complex; Sea4p, along with Rtc1p and Mtc5p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; contains an N-terminal beta-propeller fold and a C-terminal RING motif | SEA4 | | WN66_00137

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[+]  | gene2804 | WN66_02763 | protein_coding | Gene | YHL031C~GOS1~Verified | SGD:S000001023 | v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28 | GOS1 | | WN66_02763

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[+]  | gene2805 | WN66_02764 | protein_coding | Gene | YHL030W-A~Dubious | SGD:S000028773 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene GOS1/YHL031C | | | WN66_02764

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[+]  | gene801 | WN66_00792 | protein_coding | Gene | YDL239C~ADY3~Verified | SGD:S000002398 | Protein required for spore wall formation; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; mediates assembly of the LEP complex, formation of the ring-like structure via interaction with spindle pole body components and prospore membrane maturation; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole | ADY3 | | WN66_00792

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[+]  ARN6 | gene3121 | ARN6 | protein_coding | Gene | potentially novel~GTK30I00230 | | | | | WN66_03077

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[+]  | gene4181 | WN66_04125 | protein_coding | Gene | YLL048C~YBT1,BAT1~Verified | SGD:S000003971 | Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication | YBT1 | | WN66_04125

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[+]  | gene5741 | WN66_05653 | protein_coding | Gene | YOL149W~DCP1~Verified | SGD:S000005509 | Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress | DCP1 | | WN66_05653

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[+]  | gene5301 | WN66_05217 | protein_coding | Gene | YNL317W~PFS2~Verified | SGD:S000005261 | Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex | PFS2 | | WN66_05217

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[+]  | gene3388 | WN66_03342 | pseudogene | Gene | potentially novel~GTK30J00260 | | | | true | WN66_03342

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[+]  | gene3810 | WN66_03759 | protein_coding | Gene | YKL215C~OXP1~Verified | SGD:S000001698 | 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress | OXP1 | | WN66_03759

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[+]  | gene613 | WN66_00607 | protein_coding | Gene | YCL052C~PBN1~Verified | SGD:S000000557 | Component of glycosylphosphatidylinositol-mannosyltransferase I; essential component; required for the autocatalytic post-translational processing of the protease B precursor Prb1p; localizes to ER in lumenal orientation; homolog of mammalian PIG-X | PBN1 | | WN66_00607

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[+]  | gene6938 | WN66_06790 | pseudogene | Gene | BI3 | | | | true | WN66_06790

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[+]  | gene6936 | WN66_06788 | pseudogene | Gene | Q0115~BI3~Verified | | | | true | WN66_06788

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[+]  | gene4182 | WN66_04126 | protein_coding | Gene | YLL047W~Dubious | SGD:S000003970 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1 | | | WN66_04126

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[+]  | gene4768 | WN66_04686 | protein_coding | Gene | YML115C~VAN1,LDB13,VRG7,VRG8~Verified | SGD:S000004583 | Component of the mannan polymerase I; complex contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant | VAN1 | | WN66_04686

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[+]  | gene6356 | WN66_06267 | protein_coding | Gene | YPL262W~FUM1~Verified | SGD:S000006183 | Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria | FUM1 | | WN66_06267

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[+]  | gene4183 | WN66_04127 | protein_coding | Gene | YLL046C~RNP1~Verified | SGD:S000003969 | Ribonucleoprotein that contains two RNA recognition motifs (RRM); RNP1 has a paralog, SBP1, that arose from the whole genome duplication | RNP1 | | WN66_04127

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[+]  | gene5302 | WN66_05218 | protein_coding | Gene | YNL316C~PHA2~Verified | SGD:S000005260 | Prephenate dehydratase; catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway | PHA2 | | WN66_05218

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[+]  | gene1673 | WN66_01651 | protein_coding | Gene | YEL061C~CIN8,KSL2,SDS15~Verified | SGD:S000000787 | Kinesin motor protein; involved in mitotic spindle assembly and chromosome segregation | CIN8 | | WN66_01651

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[+]  | gene2012 | WN66_01986 | protein_coding | Gene | potentially novel~GTK30F00220 | | | | | WN66_01986

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[+]  | gene3811 | WN66_03760 | protein_coding | Gene | YKL214C~YRA2~Verified | SGD:S000001697 | Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus | YRA2 | | WN66_03760

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