Feature Listing

[+]  | YBR175W~SWD3,CPS30,SAF35~Verified | WN66_00445 | protein_coding | Gene | gene450 | SGD:S000000379 | Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 | SWD3 | | WN66_00445

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[+]  | YBR176W~ECM31~Verified | WN66_00446 | protein_coding | Gene | gene451 | SGD:S000000380 | Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate | ECM31 | | WN66_00446

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[+]  | YBR177C~EHT1~Verified | WN66_00447 | protein_coding | Gene | gene452 | SGD:S000000381 | Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication | EHT1 | | WN66_00447

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[+]  | YBR178W~Dubious | WN66_00448 | protein_coding | Gene | gene453 | SGD:S000000382 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C | | | WN66_00448

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[+]  | YBR179C~FZO1~Verified | WN66_00449 | protein_coding | Gene | gene454 | SGD:S000000383 | Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system | FZO1 | | WN66_00449

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[+]  | YBR180W~DTR1~Verified | WN66_00450 | protein_coding | Gene | gene455 | SGD:S000000384 | Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation | DTR1 | | WN66_00450

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[+]  | YBR181C~RPS6B,LPG18,RPS101,RPS102~Verified | WN66_00451 | protein_coding | Gene | gene456 | SGD:S000000385 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication | RPS6B | | WN66_00451

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[+]  | YBR182C~SMP1~Verified | WN66_00452 | protein_coding | Gene | gene457 | SGD:S000000386 | MADS-box transcription factor involved in osmotic stress response; SMP1 has a paralog, RLM1, that arose from the whole genome duplication | SMP1 | | WN66_00452

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[+]  | YBR182C-A~Uncharacterized | WN66_00453 | protein_coding | Gene | gene458 | SGD:S000028603 | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching | | | WN66_00453

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[+]  | YBR183W~YPC1~Verified | WN66_00454 | protein_coding | Gene | gene459 | SGD:S000000387 | Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication | YPC1 | | WN66_00454

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[+]  | YBR184W~Uncharacterized | WN66_00455 | protein_coding | Gene | gene460 | SGD:S000000388 | Putative protein of unknown function; YBR184W is not an essential gene | | | WN66_00455

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[+]  | YBR185C~MBA1~Verified | WN66_00456 | protein_coding | Gene | gene461 | SGD:S000000389 | Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane | MBA1 | | WN66_00456

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[+]  | YBR186W~PCH2~Verified | WN66_00457 | protein_coding | Gene | gene462 | SGD:S000000390 | Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in rDNA; required for meiotic double-stranded break formation | PCH2 | | WN66_00457

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[+]  | YBR187W~GDT1~Verified | WN66_00458 | protein_coding | Gene | gene463 | SGD:S000000391 | Calcium transporter localized to the cis- and medial-Golgi apparatus; required for protein glycosylation; GFP-fusion protein localizes to the vacuole; TMEM165, a human gene which causes Congenital Disorders of Glycosylation is orthologous and functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression reduced in a gcr1 null mutant | GDT1 | | WN66_00458

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[+]  | YBR188C~NTC20~Verified | WN66_00459 | protein_coding | Gene | gene464 | SGD:S000000392 | Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs | NTC20 | | WN66_00459

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[+]  | YBR189W~RPS9B,RPS13A,SUP46~Verified | WN66_00460 | protein_coding | Gene | gene465 | SGD:S000000393 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication | RPS9B | | WN66_00460

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[+]  | YBR191W~RPL21A,URP1~Verified | WN66_00461 | protein_coding | Gene | gene466 | SGD:S000000395 | Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication | RPL21A | | WN66_00461

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[+]  | YBR191W-A~Dubious | WN66_00462 | protein_coding | Gene | gene467 | SGD:S000007594 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | | WN66_00462

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[+]  | YBR192W~RIM2,PYT1~Verified | WN66_00463 | protein_coding | Gene | gene468 | SGD:S000000396 | Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family | RIM2 | | WN66_00463

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[+]  | YBR193C~MED8~Verified | WN66_00464 | protein_coding | Gene | gene469 | SGD:S000000397 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation | MED8 | | WN66_00464

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[+]  | YBR194W~AIM4,SOY1~Verified | WN66_00465 | protein_coding | Gene | gene470 | SGD:S000000398 | Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress | AIM4 | | WN66_00465

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[+]  | YBR195C~MSI1,CAC3~Verified | WN66_00466 | protein_coding | Gene | gene471 | SGD:S000000399 | Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase | MSI1 | | WN66_00466

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[+]  | YBR196C~PGI1,CDC30~Verified | WN66_00467 | protein_coding | Gene | gene472 | SGD:S000000400 | Glycolytic enzyme phosphoglucose isomerase; catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation | PGI1 | | WN66_00467

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[+]  | YBR196C-A~Uncharacterized | WN66_00468 | protein_coding | Gene | gene473 | SGD:S000028534 | Putative protein of unknown function; identified by fungal homology and RT-PCR | | | WN66_00468

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[+]  | YBR196C-B~Uncharacterized | WN66_00469 | protein_coding | Gene | gene474 | SGD:S000028816 | Putative protein of unknown function; identified by expression profiling and mass spectrometry | | | WN66_00469

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[+]  | YBR197C~Verified | WN66_00470 | protein_coding | Gene | gene475 | SGD:S000000401 | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication | | | WN66_00470

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[+]  | YBR198C~TAF5,TAF90~Verified | WN66_00471 | protein_coding | Gene | gene476 | SGD:S000000402 | Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification | TAF5 | | WN66_00471

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[+]  | YBR199W~KTR4~Verified | WN66_00472 | protein_coding | Gene | gene477 | SGD:S000000403 | Glycosyltransferase involved in protein glycosylation; transfers GDP-mannose to methyl-alpha-mannoside in vitro; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus, a membrane-spanning region and a highly conserved catalytic lumenal domain | KTR4 | | WN66_00472

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[+]  | YBR200W~BEM1,SRO1~Verified | WN66_00473 | protein_coding | Gene | gene478 | SGD:S000000404 | Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p | BEM1 | | WN66_00473

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[+]  | YBR200W-A~Uncharacterized | WN66_00474 | protein_coding | Gene | gene479 | SGD:S000028535 | Putative protein of unknown function; identified by fungal homology and RT-PCR | | | WN66_00474

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[+]  | YBR201W~DER1~Verified | WN66_00475 | protein_coding | Gene | gene480 | SGD:S000000405 | ER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled proteins; initiates export of aberrant polypeptides from ER lumen by threading them into ER membrane and routing them to Hrd1p for ubiquitylation; function normally requires N-terminal acetylation by NatB; N- and C- termini protrude into cytoplasm; similar to Dfm1p; homolog of mammalian derlin-1 | DER1 | | WN66_00475

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[+]  | YBR201C-A~Uncharacterized | WN66_00476 | protein_coding | Gene | gene481 | SGD:S000087085 | Putative protein of unknown function | | | WN66_00476

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[+]  | YBR202W~MCM7,CDC47~Verified | WN66_00477 | protein_coding | Gene | gene482 | SGD:S000000406 | Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex | MCM7 | | WN66_00477

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[+]  | YBR203W~COS111~Verified | WN66_00478 | protein_coding | Gene | gene483 | SGD:S000000407 | Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies | COS111 | | WN66_00478

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[+]  | YBR204C~Verified | WN66_00479 | protein_coding | Gene | gene484 | SGD:S000000408 | Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif) | LDH1 | | WN66_00479

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[+]  | YBR205W~KTR3~Verified | WN66_00480 | protein_coding | Gene | gene485 | SGD:S000000409 | Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress | KTR3 | | WN66_00480

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[+]  | YBR207W~FTH1~Verified | WN66_00481 | protein_coding | Gene | gene486 | SGD:S000000411 | Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress | FTH1 | | WN66_00481

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[+]  | YBR208C~DUR1%2C2,DUR80~Verified | WN66_00482 | protein_coding | Gene | gene487 | SGD:S000000412 | Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress | DUR1,2 | | WN66_00482

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[+]  | YBR209W~Dubious | WN66_00483 | protein_coding | Gene | gene488 | SGD:S000000413 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene | | | WN66_00483

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[+]  | tC(GCA)B | WN66_00484 | tRNA | Gene | gene489 | | | | | WN66_00484

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[+]  | tE(UUC)B | WN66_00485 | tRNA | Gene | gene490 | | | | | WN66_00485

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[+]  | YBR210W~ERV15~Verified | WN66_00486 | protein_coding | Gene | gene491 | SGD:S000000414 | Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication | ERV15 | | WN66_00486

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[+]  | YBR211C~AME1,ARP100~Verified | WN66_00487 | protein_coding | Gene | gene492 | SGD:S000000415 | Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress | AME1 | | WN66_00487

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[+]  | YBR212W~NGR1,RBP1~Verified | WN66_00488 | protein_coding | Gene | gene493 | SGD:S000000416 | RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase | NGR1 | | WN66_00488

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[+]  | YBR213W~MET8~Verified | WN66_00489 | protein_coding | Gene | gene494 | SGD:S000000417 | Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis | MET8 | | WN66_00489

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[+]  | YBR214W~SDS24~Verified | WN66_00490 | protein_coding | Gene | gene495 | SGD:S000000418 | Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication | SDS24 | | WN66_00490

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[+]  | YBR215W~HPC2~Verified | WN66_00491 | protein_coding | Gene | gene496 | SGD:S000000419 | Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes | HPC2 | | WN66_00491

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[+]  | YBR216C~YBP1~Verified | WN66_00492 | protein_coding | Gene | gene497 | SGD:S000000420 | Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication | YBP1 | | WN66_00492

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[+]  | YBR217W~ATG12,APG12~Verified | WN66_00493 | protein_coding | Gene | gene498 | SGD:S000000421 | Ubiquitin-like modifier involved in autophagy and the Cvt pathway; conserved; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation | ATG12 | | WN66_00493

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[+]  | YBR218C~PYC2~Verified | WN66_00494 | protein_coding | Gene | gene499 | SGD:S000000422 | Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication | PYC2 | | WN66_00494

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