Feature Listing

[+]  | YBL094C~Dubious | WN66_00149 | protein_coding | Gene | gene150 | SGD:S000000190 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W | | | WN66_00149

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[+]  | YBL093C~ROX3,MED19,NUT3,SSN7~Verified | WN66_00150 | protein_coding | Gene | gene151 | SGD:S000000189 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme | ROX3 | | WN66_00150

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[+]  | YBL092W~RPL32~Verified | WN66_00151 | protein_coding | Gene | gene152 | SGD:S000000188 | Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog | RPL32 | | WN66_00151

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[+]  | YBL091C-A~SCS22~Verified | WN66_00152 | protein_coding | Gene | gene153 | SGD:S000007228 | Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect the ER and plasma membrane (PM); regulates PM PI4P levels by controlling access of the Sac1p phosphatase to its substrate, PI4P; human VAP homolog; similar to D. melanogaster inturned protein; SWAT-GFP and mCherry fusion proteins localize to the cytosol; SCS22 has a paralog, SCS2, that arose from the whole genome duplication | SCS22 | | WN66_00152

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[+]  | YBL091C~MAP2~Verified | WN66_00153 | protein_coding | Gene | gene154 | SGD:S000000187 | Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p | MAP2 | | WN66_00153

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[+]  | YBL090W~MRP21,MRP50~Verified | WN66_00154 | protein_coding | Gene | gene155 | SGD:S000000186 | Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences | MRP21 | | WN66_00154

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[+]  | YBL089W~AVT5~Verified | WN66_00155 | protein_coding | Gene | gene156 | SGD:S000000185 | Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication | AVT5 | | WN66_00155

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[+]  | YBL088C~TEL1~Verified | WN66_00156 | protein_coding | Gene | gene157 | SGD:S000000184 | Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; acts with Red1p and Mec1p to promote interhomolog recombination by phosphorylation of Hop1; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene | TEL1 | | WN66_00156

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[+]  | YBL087C~RPL23A~Verified | WN66_00157 | protein_coding | Gene | gene158 | SGD:S000000183 | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication | RPL23A | | WN66_00157

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[+]  | YBL086C~Uncharacterized | WN66_00158 | protein_coding | Gene | gene159 | SGD:S000000182 | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery | | | WN66_00158

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[+]  | YBL085W~BOI1,BOB1,GIN7~Verified | WN66_00159 | protein_coding | Gene | gene160 | SGD:S000000181 | Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication | BOI1 | | WN66_00159

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[+]  | YBL084C~CDC27,APC3,SNB1~Verified | WN66_00160 | protein_coding | Gene | gene161 | SGD:S000000180 | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition | CDC27 | | WN66_00160

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[+]  | YBL082C~ALG3,RHK1~Verified | WN66_00161 | protein_coding | Gene | gene162 | SGD:S000000178 | Dolichol-P-Man dependent alpha(1-3) mannosyltransferase; involved in synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; G353A missense mutation in human ortholog ALG3 implicated in carbohydrate deficient glycoprotein syndrome type IV, which is characterized by microcephaly, severe epilepsy, minimal psychomotor development, partial deficiency of sialic acids in serum glycoproteins; wild-type human ALG3 can complement yeast alg3 mutant | ALG3 | | WN66_00161

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[+]  | YBL081W~Uncharacterized | WN66_00162 | protein_coding | Gene | gene163 | | | | | WN66_00162

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[+]  | YBL080C~PET112~Verified | WN66_00163 | protein_coding | Gene | gene164 | SGD:S000000176 | Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog | PET112 | | WN66_00163

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[+]  | YBL079W~NUP170,NLE3~Verified | WN66_00164 | protein_coding | Gene | gene165 | SGD:S000000175 | Subunit of inner ring of nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; interacts with genomic regions that contain ribosomal protein and subtelomeric genes, where it functions in nucleosome positioning and as a repressor of transcription; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication | NUP170 | | WN66_00164

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[+]  | YBL078C~ATG8,APG8,AUT7,CVT5~Verified | WN66_00165 | protein_coding | Gene | gene166 | SGD:S000000174 | Component of autophagosomes and Cvt vesicles; regulator of Atg1p, targets it to autophagosomes; binds the Atg1p-Atg13p complex, triggering its vacuolar degradation; unique ubiquitin-like protein whose conjugation target is lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis | ATG8 | | WN66_00165

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[+]  | YBL077W~Dubious | WN66_00166 | protein_coding | Gene | gene167 | SGD:S000000173 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C | | | WN66_00166

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[+]  | YBL076C~ILS1~Verified | WN66_00167 | protein_coding | Gene | gene168 | SGD:S000000172 | Cytoplasmic isoleucine-tRNA synthetase; target of the G1-specific inhibitor reveromycin A | ILS1 | | WN66_00167

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[+]  | YBL075C~SSA3,YG106~Verified | WN66_00168 | protein_coding | Gene | gene169 | SGD:S000000171 | ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication | SSA3 | | WN66_00168

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[+]  | YBL074C~AAR2~Verified | WN66_00169 | protein_coding | Gene | gene170 | SGD:S000000170 | Component of the U5 snRNP complex; required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron | AAR2 | | WN66_00169

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[+]  | YBL073W~Dubious | WN66_00170 | protein_coding | Gene | gene171 | SGD:S000000169 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C | | | WN66_00170

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[+]  | | WN66_00171 | snoRNA | Gene | gene172 | | | | | WN66_00171

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[+]  | YBL072C~RPS8A~Verified | WN66_00172 | protein_coding | Gene | gene173 | SGD:S000000168 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication | RPS8A | | WN66_00172

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[+]  | YBL071C-B~Uncharacterized | WN66_00173 | protein_coding | Gene | gene174 | SGD:S000028597 | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching | | | WN66_00173

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[+]  | YBL071W-A~KTI11,DPH3~Verified | WN66_00174 | protein_coding | Gene | gene175 | SGD:S000007587 | Zn-ribbon protein that co-purifies with Dph1 and Dph2; in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p; involved in modification of wobble nucleosides in tRNAs; forms a stable heterodimer with Ats1p | KTI11 | | WN66_00174

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[+]  | YBL071C~Dubious | WN66_00175 | protein_coding | Gene | gene176 | SGD:S000000167 | Putative protein of unknown function; conserved among S. cerevisiae strains; YBL071C is not an essential gene | | | WN66_00175

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[+]  | YBL070C~Dubious | WN66_00176 | pseudogene | Gene | gene177 | SGD:S000000166 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | true | WN66_00176

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[+]  | YBL069W~AST1~Verified | WN66_00177 | protein_coding | Gene | gene178 | SGD:S000000165 | Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication | AST1 | | WN66_00177

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[+]  | YBL068W~PRS4~Verified | WN66_00178 | protein_coding | Gene | gene179 | SGD:S000000164 | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic | PRS4 | | WN66_00178

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[+]  | YBL067C~UBP13~Verified | WN66_00179 | protein_coding | Gene | gene180 | SGD:S000000163 | Ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication | UBP13 | | WN66_00179

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[+]  | YBL066C~SEF1~Verified | WN66_00180 | protein_coding | Gene | gene181 | SGD:S000000162 | Putative transcription factor; has homolog in Kluyveromyces lactis | SEF1 | | WN66_00180

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[+]  | YBL065W~Dubious | WN66_00181 | protein_coding | Gene | gene182 | SGD:S000000161 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene | | | WN66_00181

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[+]  | YBL064C~PRX1~Verified | WN66_00182 | protein_coding | Gene | gene183 | SGD:S000000160 | Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress | PRX1 | | WN66_00182

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[+]  | YBL063W~KIP1,CIN9~Verified | WN66_00183 | protein_coding | Gene | gene184 | SGD:S000000159 | Kinesin-related motor protein; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions | KIP1 | | WN66_00183

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[+]  | YBL062W~Dubious | WN66_00184 | protein_coding | Gene | gene185 | SGD:S000000158 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | | WN66_00184

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[+]  | YBL061C~SKT5,CAL2,CHS4,CSD4~Verified | WN66_00185 | protein_coding | Gene | gene186 | SGD:S000000157 | Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication | SKT5 | | WN66_00185

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[+]  | YBL060W~YEL1~Verified | WN66_00186 | protein_coding | Gene | gene187 | SGD:S000000156 | Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip | YEL1 | | WN66_00186

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[+]  | YBL059C-A~CMC2~Verified | WN66_00187 | protein_coding | Gene | gene188 | SGD:S000007488 | Protein involved in respiratory chain complex assembly or maintenance; protein of the mitochondrial intermembrane space; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold | CMC2 | | WN66_00187

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[+]  | YBL059W~Uncharacterized | WN66_00188 | protein_coding | Gene | gene189 | SGD:S000000155 | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication | | | WN66_00188

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[+]  | YBL058W~SHP1,UBX1~Verified | WN66_00189 | protein_coding | Gene | gene190 | SGD:S000000154 | UBX domain-containing substrate adaptor for Cdc48p; ubiquitin regulatory X domain-containing protein that acts as a substrate recruiting cofactor for Cdc48p; positively regulates Glc7p PPase activity to promote growth and mitotic progression in complex with Cdc48p; ubiquitinated protein interactor involved in ER-associated degradation (ERAD); regulated by nuclear Ub-dependent degradation (INMAD pathway) independent of the Asi and Doa10 complexes; homolog of human p47 (NSFL1C) | SHP1 | | WN66_00189

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[+]  | YBL057C~PTH2~Verified | WN66_00190 | protein_coding | Gene | gene191 | SGD:S000000153 | One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1 | PTH2 | | WN66_00190

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[+]  | YBL056W~PTC3~Verified | WN66_00191 | protein_coding | Gene | gene192 | SGD:S000000152 | Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication | PTC3 | | WN66_00191

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[+]  | YBL055C~Tat-D~Verified | WN66_00192 | protein_coding | Gene | gene193 | SGD:S000000151 | 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases | | | WN66_00192

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[+]  | YBL054W~TOD6,PBF1~Verified | WN66_00193 | protein_coding | Gene | gene194 | SGD:S000000150 | PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; activated in stochastic pulses of nuclear localization | TOD6 | | WN66_00193

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[+]  | YBL053W~Dubious | WN66_00194 | protein_coding | Gene | gene195 | SGD:S000000149 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | | WN66_00194

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[+]  | YBL052C~SAS3~Verified | WN66_00195 | protein_coding | Gene | gene196 | SGD:S000000148 | Histone acetyltransferase catalytic subunit of NuA3 complex; acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal | SAS3 | | WN66_00195

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[+]  | YBL051C~PIN4,MDT1~Verified | WN66_00196 | protein_coding | Gene | gene197 | SGD:S000000147 | Protein involved in G2/M phase progression and response to DNA damage; interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage | PIN4 | | WN66_00196

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[+]  | YBL050W~SEC17,RNS3~Verified | WN66_00197 | protein_coding | Gene | gene198 | SGD:S000000146 | Alpha-SNAP cochaperone; SNARE-complex adaptor for Sec18 (NSF) during the disassembly of postfusion cis-SNARE complexes; stimulates the ATPase activity of Sec18p; peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; similar to mammalian alpha-SNAP | SEC17 | | WN66_00197

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[+]  | YBL049W~MOH1~Verified | WN66_00198 | protein_coding | Gene | gene199 | SGD:S000000145 | Protein of unknown function, essential for stationary phase survival; not required for growth on nonfermentable carbon sources; possibly linked with vacuolar transport | MOH1 | | WN66_00198

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