Feature Listing

[+]  | YBR082C~UBC4~Verified | WN66_00345 | protein_coding | Gene | gene350 | SGD:S000000286 | Ubiquitin-conjugating enzyme (E2); key E2 partner with Ubc1p for the anaphase-promoting complex (APC); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication | UBC4 | | WN66_00345

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[+]  | YBR083W~TEC1,ROC1~Verified | WN66_00346 | protein_coding | Gene | gene351 | SGD:S000000287 | Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member | TEC1 | | WN66_00346

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[+]  | YBR084W~MIS1~Verified | WN66_00347 | protein_coding | Gene | gene352 | SGD:S000000288 | Mitochondrial C1-tetrahydrofolate synthase; involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase | MIS1 | | WN66_00347

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[+]  | YBR084C-A~RPL19A~Verified | WN66_00348 | protein_coding | Gene | gene353 | SGD:S000002156 | Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication | RPL19A | | WN66_00348

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[+]  | YBR085W~AAC3,ANC3~Verified | WN66_00349 | protein_coding | Gene | gene354 | SGD:S000000289 | Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication | AAC3 | | WN66_00349

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[+]  | YBR085C-A~Verified | WN66_00350 | protein_coding | Gene | gene355 | SGD:S000007522 | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress | | | WN66_00350

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[+]  | YBR086C~IST2~Verified | WN66_00351 | protein_coding | Gene | gene356 | SGD:S000000290 | Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process | IST2 | | WN66_00351

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[+]  | YBR087W~RFC5~Verified | WN66_00352 | protein_coding | Gene | gene357 | SGD:S000000291 | Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon | RFC5 | | WN66_00352

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[+]  | YBR088C~POL30~Verified | WN66_00353 | protein_coding | Gene | gene358 | SGD:S000000292 | Proliferating cell nuclear antigen (PCNA); functions as the sliding replication clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; PCNA ubiquitination at K164 plays a crucial role during Okazaki fragment processing | POL30 | | WN66_00353

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[+]  | YBR089W~Dubious | WN66_00354 | pseudogene | Gene | gene359 | SGD:S000000293 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30 | | true | WN66_00354

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[+]  | YBR089C-A~NHP6B,YBR090C-A~Verified | WN66_00355 | protein_coding | Gene | gene360 | SGD:S000002157 | High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication | NHP6B | | WN66_00355

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[+]  | YBR091C~TIM12,MRS5~Verified | WN66_00356 | protein_coding | Gene | gene361 | SGD:S000000295 | Essential protein of the inner mitochondrial membrane; peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins | TIM12 | | WN66_00356

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[+]  | YBR092C~PHO3,phoC~Verified | WN66_00357 | protein_coding | Gene | gene362 | SGD:S000000296 | Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin | PHO3 | | WN66_00357

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[+]  | YBR093C~PHO5,phoE~Verified | WN66_00358 | protein_coding | Gene | gene363 | SGD:S000000297 | Repressible acid phosphatase; 1 of 3 repressible acid phosphatases that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 | PHO5 | | WN66_00358

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[+]  | YBR094W~PBY1~Verified | WN66_00359 | protein_coding | Gene | gene364 | SGD:S000000298 | Putative tubulin tyrosine ligase associated with P-bodies; may have a role in mRNA metabolism; yeast knockout collection strain identified as a pby1 null mutant is actually wild-type for PBY1 and deleted for mms4 | PBY1 | | WN66_00359

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[+]  | YBR095C~RXT2,RAF60~Verified | WN66_00360 | protein_coding | Gene | gene365 | SGD:S000000299 | Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia | RXT2 | | WN66_00360

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[+]  | YBR096W~Uncharacterized | WN66_00361 | protein_coding | Gene | gene366 | SGD:S000000300 | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER | | | WN66_00361

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[+]  | YBR097W~VPS15,GRD8,VAC4,VPL19,VPS40~Verified | WN66_00362 | protein_coding | Gene | gene367 | SGD:S000000301 | Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery | VPS15 | | WN66_00362

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[+]  | YBR098W~MMS4,SLX2,YBR100W~Verified | WN66_00363 | protein_coding | Gene | gene368 | SGD:S000000302 | Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdc5p during mitotic cell cycle activates the function of Mms4p-Mus81p | MMS4 | | WN66_00363

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[+]  | YBR099C~Dubious | WN66_00364 | protein_coding | Gene | gene369 | SGD:S000000303 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4 | | | WN66_00364

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[+]  | YBR101C~FES1~Verified | WN66_00365 | protein_coding | Gene | gene370 | SGD:S000000305 | Hsp70 (Ssa1p) nucleotide exchange factor; required for the release of misfolded proteins from the Hsp70 system to the Ub-proteasome machinery for destruction; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress | FES1 | | WN66_00365

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[+]  | YBR102C~EXO84,USA3~Verified | WN66_00366 | protein_coding | Gene | gene371 | SGD:S000000306 | Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate | EXO84 | | WN66_00366

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[+]  | YBR103W~SIF2,EMB1~Verified | WN66_00367 | protein_coding | Gene | gene372 | SGD:S000000307 | WD40 repeat-containing subunit of Set3C histone deacetylase complex; complex represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus | SIF2 | | WN66_00367

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[+]  | YBR103C-A~Dubious | WN66_00368 | protein_coding | Gene | gene373 | SGD:S000007593 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by homology to related yeast | | | WN66_00368

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[+]  | YBR104W~YMC2~Verified | WN66_00369 | protein_coding | Gene | gene374 | SGD:S000000308 | Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication | YMC2 | | WN66_00369

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[+]  | YBR105C~VID24,GID4~Verified | WN66_00370 | protein_coding | Gene | gene375 | SGD:S000000309 | GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles | VID24 | | WN66_00370

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[+]  | YBR106W~PHO88~Verified | WN66_00371 | protein_coding | Gene | gene376 | SGD:S000000310 | Probable membrane protein; involved in phosphate transport; role in the maturation of secretory proteins; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations | PHO88 | | WN66_00371

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[+]  | YBR107C~IML3,MCM19~Verified | WN66_00372 | protein_coding | Gene | gene377 | SGD:S000000311 | Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; forms a stable complex with Chl4p; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1 | IML3 | | WN66_00372

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[+]  | YBR108W~AIM3~Verified | WN66_00373 | protein_coding | Gene | gene378 | SGD:S000000312 | Protein that inhibits barbed-end actin filament elongation; interacts with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss | AIM3 | | WN66_00373

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[+]  | YBR109C~CMD1,CaM~Verified | WN66_00374 | protein_coding | Gene | gene379 | SGD:S000000313 | Calmodulin; Ca2+ binding protein that regulates Ca2+ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca2+ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin; binds to the Hog1p MAPK in response to hyperosmotic stress; potentiates membrane tubulation and constriction mediated by the Rvs161p-Rvs167p complex; human CALM1 or CALM2 functionally complement repression induced inviability | CMD1 | | WN66_00374

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[+]  | YBR109W-A~Dubious | WN66_00375 | protein_coding | Gene | gene380 | SGD:S000028737 | Putative protein of unknown function; questionable ORF from MIPS | | | WN66_00375

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[+]  | YBR110W~ALG1~Verified | WN66_00376 | protein_coding | Gene | gene381 | SGD:S000000314 | Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant | ALG1 | | WN66_00376

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[+]  | YBR111C~YSA1,RMA2~Verified | WN66_00377 | protein_coding | Gene | gene382 | SGD:S000000315 | Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate | YSA1 | | WN66_00377

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[+]  | YBR111W-A~SUS1~Verified | WN66_00378 | protein_coding | Gene | gene383 | SGD:S000028510 | Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP | SUS1 | | WN66_00378

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[+]  | YBR112C~CYC8,CRT8,SSN6~Verified | WN66_00379 | protein_coding | Gene | gene384 | SGD:S000000316 | General transcriptional co-repressor; acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+] | CYC8 | | WN66_00379

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[+]  | YBR113W~Dubious | WN66_00380 | protein_coding | Gene | gene385 | SGD:S000000317 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8 | | | WN66_00380

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[+]  | YBR114W~RAD16,PSO5~Verified | WN66_00381 | protein_coding | Gene | gene386 | SGD:S000000318 | Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex | RAD16 | | WN66_00381

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[+]  | YBR115C~LYS2~Verified | WN66_00382 | protein_coding | Gene | gene387 | SGD:S000000319 | Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p | LYS2 | | WN66_00382

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[+]  | YBR117C~TKL2~Verified | WN66_00383 | protein_coding | Gene | gene388 | SGD:S000000321 | Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL2 has a paralog, TKL1, that arose from the whole genome duplication | TKL2 | | WN66_00383

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[+]  | YBR118W~TEF2,EF-1%20alpha~Verified | WN66_00384 | protein_coding | Gene | gene389 | SGD:S000000322 | Translational elongation factor EF-1 alpha; in the GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; associates with vacuolar Rho1p GTPase; TEF2-RFP levels increase during replicative aging; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication | TEF2 | | WN66_00384

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[+]  | YBR119W~MUD1~Verified | WN66_00385 | protein_coding | Gene | gene390 | SGD:S000000323 | U1 snRNP A protein; homolog of human U1-A; involved in nuclear mRNA splicing | MUD1 | | WN66_00385

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[+]  | YBR120C~CBP6~Verified | WN66_00386 | protein_coding | Gene | gene391 | SGD:S000000324 | Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation | CBP6 | | WN66_00386

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[+]  | YBR121C~GRS1~Verified | WN66_00387 | protein_coding | Gene | gene392 | SGD:S000000325 | Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication; human homolog GARS implicated in Charcot-Marie-Tooth disease, can complement yeast null mutant | GRS1 | | WN66_00387

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[+]  | YBR122C~MRPL36~Verified | WN66_00388 | protein_coding | Gene | gene393 | SGD:S000000326 | Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region | MRPL36 | | WN66_00388

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[+]  | YBR123C~TFC1~Verified | WN66_00389 | protein_coding | Gene | gene394 | SGD:S000000327 | Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63 | TFC1 | | WN66_00389

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[+]  | YBR124W~Dubious | WN66_00390 | protein_coding | Gene | gene395 | SGD:S000000328 | Putative protein of unknown function | | | WN66_00390

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[+]  | YBR125C~PTC4,GCT1~Verified | WN66_00391 | protein_coding | Gene | gene396 | SGD:S000000329 | Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity | PTC4 | | WN66_00391

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[+]  | YBR126C~TPS1,BYP1,CIF1,FDP1,GGS1,GLC6,TSS1~Verified | WN66_00392 | protein_coding | Gene | gene397 | SGD:S000000330 | Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose, which is critically important for survival of long-term desiccation; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid | TPS1 | | WN66_00392

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[+]  | YBR126W-A~Uncharacterized | WN66_00393 | protein_coding | Gene | gene398 | SGD:S000028600 | Putative protein of unknown function; identified by gene-trapping, microarray analysis, and genome-wide homology searches; mRNA identified as translated by ribosome profiling data; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; partially overlaps the dubious ORF YBR126W-B | MEO1 | | WN66_00393

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[+]  | YBR126W-B~Dubious | WN66_00394 | protein_coding | Gene | gene399 | SGD:S000028738 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-A; identified by SAGE | | | WN66_00394

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