Feature Listing

[+]  | YDR542W~PAU10~Verified | WN66_01637 | protein_coding | Gene | gene1657 | SGD:S000002950 | Protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to the vacuole; member of the seripauperin multigene family encoded mainly in subtelomeric regions | PAU10 | | WN66_01637

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[+]  | YDR541C~Verified | WN66_01636 | protein_coding | Gene | gene1656 | SGD:S000002949 | Aldehyde reductase; substrates include both aromatic and aliphatic aldehydes; uses NADPH as cofactor; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively | | | WN66_01636

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[+]  | YDR540C~IRC4~Verified | WN66_01635 | pseudogene | Gene | gene1655 | SGD:S000002948 | Protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus | IRC4 | true | WN66_01635

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[+]  | YDR539W~FDC1~Verified | WN66_01634 | pseudogene | Gene | gene1654 | SGD:S000002947 | Ferulic acid decarboxylase, also active on p-coumaric acid; essential for decarboxylation of aromatic carboxylic acids to corresponding vinyl derivatives; co-overproduction of Pad1p and Fdc1p greatly increases cinnamic acid decarboxylase activity; structure implicates Glu285 as the general base in the nonoxidative decarboxylation reaction catalyzed by Fdc1p; homolog of E. coli UbiD; GFP-fusion protein localizes to cytoplasm | FDC1 | true | WN66_01634

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[+]  | YDR538W~PAD1,POF1~Verified | WN66_01633 | protein_coding | Gene | gene1653 | SGD:S000002946 | Phenylacrylic acid decarboxylase; confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX; co-overproduction of Pad1p and Fdc1p greatly increases cinnamic acid decarboxylase activity | PAD1 | | WN66_01633

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[+]  | YDR537C~Dubious | WN66_01632 | protein_coding | Gene | gene1652 | SGD:S000002945 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF PAD1/YDR538W | | | WN66_01632

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[+]  | YDR536W~STL1~Verified | WN66_01631 | protein_coding | Gene | gene1651 | SGD:S000002944 | Glycerol proton symporter of the plasma membrane; subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock | STL1 | | WN66_01631

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[+]  | YDR535C~Dubious | WN66_01630 | pseudogene | Gene | gene1650 | SGD:S000002943 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene | | true | WN66_01630

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[+]  | YDR534C~Verified | WN66_01629 | protein_coding | Gene | gene1649 | | | | | WN66_01629

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[+]  | YDR533C~HSP31~Verified | WN66_01628 | protein_coding | Gene | gene1648 | SGD:S000002941 | Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress | HSP31 | | WN66_01628

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[+]  | YDR532C~KRE28~Verified | WN66_01627 | protein_coding | Gene | gene1647 | SGD:S000002940 | Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Spc105p; modified by sumoylation | KRE28 | | WN66_01627

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[+]  | YDR531W~CAB1~Verified | WN66_01626 | protein_coding | Gene | gene1646 | SGD:S000002939 | Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase; catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element | CAB1 | | WN66_01626

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[+]  | YDR530C~APA2~Verified | WN66_01625 | protein_coding | Gene | gene1645 | SGD:S000002938 | Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication | APA2 | | WN66_01625

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[+]  | YDR529C~QCR7,COR4,CRO1,UCR7~Verified | WN66_01624 | protein_coding | Gene | gene1644 | SGD:S000002937 | Subunit 7 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly | QCR7 | | WN66_01624

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[+]  | YDR528W~HLR1~Verified | WN66_01623 | protein_coding | Gene | gene1643 | SGD:S000002936 | Protein involved in regulation of cell wall composition and integrity; also involved in cell wall response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; HLR1 has a paralog, LRE1, that arose from the whole genome duplication | HLR1 | | WN66_01623

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[+]  | | WN66_01622 | snoRNA | Gene | gene1642 | | | | | WN66_01622

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[+]  | YDR527W~RBA50~Verified | WN66_01621 | protein_coding | Gene | gene1641 | SGD:S000002935 | Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 | RBA50 | | WN66_01621

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[+]  | YDR526C~Dubious | WN66_01620 | protein_coding | Gene | gene1640 | SGD:S000002934 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | | WN66_01620

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[+]  | YDR525W-A~SNA2~Verified | WN66_01619 | protein_coding | Gene | gene1639 | SGD:S000007236 | Protein of unknown function; has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern | SNA2 | | WN66_01619

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[+]  | YDR525W~API2~Dubious | WN66_01618 | protein_coding | Gene | gene1638 | SGD:S000002933 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology | API2 | | WN66_01618

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[+]  | YDR524C-A~YDR524C-C~Dubious | WN66_01617 | protein_coding | Gene | gene1637 | SGD:S000028616 | Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching | | | WN66_01617

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[+]  | YDR524C-B~Uncharacterized | WN66_01616 | protein_coding | Gene | gene1636 | SGD:S000028739 | Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication | | | WN66_01616

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[+]  | YDR524W-C~YDR524W-A~Uncharacterized | WN66_01615 | protein_coding | Gene | gene1635 | SGD:S000028740 | Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin | | | WN66_01615

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[+]  | YDR524C~AGE1,SAT1~Verified | WN66_01614 | protein_coding | Gene | gene1634 | SGD:S000002932 | ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif | AGE1 | | WN66_01614

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[+]  | YDR523C~SPS1~Verified | WN66_01613 | protein_coding | Gene | gene1633 | SGD:S000002931 | Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis | SPS1 | | WN66_01613

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[+]  | YDR522C~SPS2~Verified | WN66_01612 | protein_coding | Gene | gene1632 | SGD:S000002930 | Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component | SPS2 | | WN66_01612

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[+]  | YDR521W~Dubious | WN66_01611 | protein_coding | Gene | gene1631 | SGD:S000002929 | Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol | | | WN66_01611

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[+]  | YDR520C~URC2,RRT4~Uncharacterized | WN66_01610 | protein_coding | Gene | gene1630 | SGD:S000002928 | Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism | URC2 | | WN66_01610

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[+]  | YDR519W~FPR2,FKB2~Verified | WN66_01609 | protein_coding | Gene | gene1629 | SGD:S000002927 | Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; mutation is functionally complemented by human FKBP2 | FPR2 | | WN66_01609

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[+]  | YDR518W~EUG1~Verified | WN66_01608 | protein_coding | Gene | gene1628 | SGD:S000002926 | Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER | EUG1 | | WN66_01608

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[+]  | YDR517W~GRH1~Verified | WN66_01607 | protein_coding | Gene | gene1627 | SGD:S000002925 | Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress | GRH1 | | WN66_01607

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[+]  | YDR516C~EMI2~Verified | WN66_01606 | protein_coding | Gene | gene1626 | SGD:S000002924 | Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress | EMI2 | | WN66_01606

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[+]  | YDR515W~SLF1,SRO99~Verified | WN66_01605 | protein_coding | Gene | gene1625 | SGD:S000002923 | RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress | SLF1 | | WN66_01605

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[+]  | YDR514C~Verified | WN66_01604 | protein_coding | Gene | gene1624 | SGD:S000002922 | Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication | | | WN66_01604

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[+]  | YDR513W~GRX2,TTR1~Verified | WN66_01603 | protein_coding | Gene | gene1623 | SGD:S000002921 | Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form translocated to the mitochondrial matrix; GRX2 has a paralog, GRX1, that arose from the whole genome duplication | GRX2 | | WN66_01603

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[+]  | YDR512C~EMI1~Verified | WN66_01602 | protein_coding | Gene | gene1622 | SGD:S000002920 | Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs; deletion affects mitochondrial morphology | EMI1 | | WN66_01602

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[+]  | YDR511W~ACN9~Verified | WN66_01601 | protein_coding | Gene | gene1621 | SGD:S000002919 | Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; localized to the mitochondrial intermembrane space; required for acetate utilization and gluconeogenesis; mutation in Drosophila ortholog SDHAF3 causes reduced succinate dehydrogenase activity and neuronal and muscular dysfunction; member of the LYR protein family | SDH7 | | WN66_01601

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[+]  | YDR510C-A~Dubious | WN66_01600 | protein_coding | Gene | gene1620 | SGD:S000028615 | Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching | | | WN66_01600

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[+]  | YDR510W~SMT3~Verified | WN66_01599 | protein_coding | Gene | gene1619 | SGD:S000002918 | Ubiquitin-like protein of the SUMO family; conjugated to lysine residues of target proteins; associates with transcriptionally active genes; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; human homolog SUMO1 can complement yeast null mutant | SMT3 | | WN66_01599

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[+]  | YDR509W~Dubious | WN66_01598 | protein_coding | Gene | gene1618 | SGD:S000002917 | Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data | | | WN66_01598

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[+]  | YDR508C~GNP1~Verified | WN66_01597 | protein_coding | Gene | gene1617 | SGD:S000002916 | High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication | GNP1 | | WN66_01597

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[+]  | YDR507C~GIN4,ERC47~Verified | WN66_01596 | protein_coding | Gene | gene1616 | SGD:S000002915 | Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication | GIN4 | | WN66_01596

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[+]  | tL(CAA)D | WN66_01595 | tRNA | Gene | gene1615 | | | | | WN66_01595

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[+]  | YDR506C~Verified | WN66_01594 | protein_coding | Gene | gene1614 | SGD:S000002914 | Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively | GMC1 | | WN66_01594

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[+]  | YDR505C~PSP1,GIN5~Verified | WN66_01593 | protein_coding | Gene | gene1613 | SGD:S000002913 | Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication | PSP1 | | WN66_01593

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[+]  | YDR504C~SPG3~Verified | WN66_01592 | protein_coding | Gene | gene1612 | SGD:S000002912 | Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum | SPG3 | | WN66_01592

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[+]  | YDR503C~LPP1~Verified | WN66_01591 | protein_coding | Gene | gene1611 | SGD:S000002911 | Lipid phosphate phosphatase; catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA | LPP1 | | WN66_01591

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[+]  | YDR502C~SAM2,ETH2~Verified | WN66_01590 | protein_coding | Gene | gene1610 | SGD:S000002910 | S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon | SAM2 | | WN66_01590

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[+]  | YDR501W~PLM2~Verified | WN66_01589 | protein_coding | Gene | gene1609 | SGD:S000002909 | Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication | PLM2 | | WN66_01589

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[+]  | YDR500C~RPL37B~Verified | WN66_01588 | protein_coding | Gene | gene1608 | SGD:S000002908 | Ribosomal 60S subunit protein L37B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication | RPL37B | | WN66_01588

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