Feature Listing

[+]  | | SGD:S000004863 | gene5191 | | WN66_05107 | GTO3 | YMR251W~GTO3~Verified | WN66_05107 | protein_coding | | Omega class glutathione transferase; putative cytosolic localization | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004864 | gene5192 | | WN66_05108 | HOR7 | YMR251W-A~HOR7~Verified | WN66_05108 | protein_coding | | Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004868 | gene5196 | | WN66_05112 | GFD1 | YMR255W~GFD1~Verified | WN66_05112 | protein_coding | | Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004877 | gene5205 | | WN66_05121 | CUE1 | YMR264W~CUE1,KIS4~Verified | WN66_05121 | protein_coding | | Ubiquitin-binding protein; ER membrane protein that recruits and integrates the ubiquitin-conjugating enzyme Ubc7p into ER membrane-bound ubiquitin ligase complexes that function in the ER-associated degradation (ERAD) pathway for misfolded proteins; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination and to promote diubiquitin elongation, facilitating polyubiquitin chain formation | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004879 | gene5207 | | WN66_05123 | RSN1 | YMR266W~RSN1~Verified | WN66_05123 | protein_coding | | Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004880 | gene5208 | | WN66_05124 | PPA2 | YMR267W~PPA2,IPP2~Verified | WN66_05124 | protein_coding | | Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; human ortholog, PPA2, functionally complements the null mutant; mutations in human PPA2 cause a mitochondrial disease resulting in sudden unexpected cardiac arrest in infants | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004889 | gene5220 | | WN66_05136 | DSK2 | YMR276W~DSK2~Verified | WN66_05136 | protein_coding | | Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004890 | gene5221 | | WN66_05137 | FCP1 | YMR277W~FCP1~Verified | WN66_05137 | protein_coding | | Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004891 | gene5222 | | WN66_05138 | PRM15 | YMR278W~PGM3~Verified | WN66_05138 | protein_coding | | Phosphoribomutase; catalyzes interconversion of ribose-1-phosphate and ribose-5-phosphate; has some phosphoglucomutase activity but primary activity in vivo is phosphoribomutase; contributes to ribose recycling in the pentose phosphate pathway; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004894 | gene5225 | | WN66_05141 | GPI12 | YMR281W~GPI12~Verified | WN66_05141 | protein_coding | | ER membrane protein involved in the second step of GPI anchor assembly; the second step is the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp; GPI stands for glycosylphosphatidylinositol | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004897 | gene5229 | | WN66_05145 | YKU70 | YMR284W~YKU70,HDF1,KU70,NES24~Verified | WN66_05145 | protein_coding | | Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein to nucleus via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004899 | gene5231 | | WN66_05147 | MRPL33 | YMR286W~MRPL33~Verified | WN66_05147 | protein_coding | | Mitochondrial ribosomal protein of the large subunit | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004901 | gene5233 | | WN66_05149 | HSH155 | YMR288W~HSH155~Verified | WN66_05149 | protein_coding | | U2-snRNP associated splicing factor; forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004902 | gene5234 | | WN66_05150 | ABZ2 | YMR289W~ABZ2~Verified | WN66_05150 | protein_coding | | Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase); catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004905 | gene5236 | | WN66_05152 | TDA1 | YMR291W~Verified | WN66_05152 | protein_coding | | Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004906 | gene5237 | | WN66_05153 | GOT1 | YMR292W~GOT1~Verified | WN66_05153 | protein_coding | | Homodimeric protein that is packaged into COPII vesicles; cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004908 | gene5239 | | WN66_05155 | JNM1 | YMR294W~JNM1,INS1,PAC3~Verified | WN66_05155 | protein_coding | | Component of the yeast dynactin complex; consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004912 | gene5243 | | WN66_05159 | PRC1 | YMR297W~PRC1,LBC1~Verified | WN66_05159 | protein_coding | | Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004913 | gene5244 | | WN66_05160 | LIP1 | YMR298W~LIP1~Verified | WN66_05160 | protein_coding | | Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004843 | gene5165 | | WN66_05081 | RPS10B | YMR230W~RPS10B~Verified | WN66_05081 | protein_coding | | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication; mutations in the human homolog associated with Diamond-Blackfan anemia | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004844 | gene5167 | | WN66_05083 | PEP5 | YMR231W~PEP5,END1,VAM1,VPL9,VPS11,VPT11~Verified | WN66_05083 | protein_coding | | Histone E3 ligase, component of CORVET membrane tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; involved in ubiquitylation and degradation of excess histones | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004845 | gene5168 | | WN66_05084 | FUS2 | YMR232W~FUS2~Verified | WN66_05084 | protein_coding | | Cell fusion regulator; cytoplasmic protein localized to shmoo tip; required for alignment of parental nuclei before nuclear fusion during mating; contains a Dbl-homology domain; binds specifically with activated Cdc42p | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004847 | gene5170 | | WN66_05086 | RNH1 | YMR234W~RNH1~Verified | WN66_05086 | protein_coding | | Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I. | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004849 | gene5172 | | WN66_05088 | TAF9 | YMR236W~TAF9,TAF17~Verified | WN66_05088 | protein_coding | | Subunit (17 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3 | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004850 | gene5173 | | WN66_05089 | BCH1 | YMR237W~BCH1~Verified | WN66_05089 | protein_coding | | Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; interacts selectively with the activated, GTP-bound form of Arf1p; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004851 | gene5174 | | WN66_05090 | DFG5 | YMR238W~DFG5~Verified | WN66_05090 | protein_coding | | Putative mannosidase; essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000005243 | gene5318 | | WN66_05234 | TRF5 | YNL299W~TRF5~Verified | WN66_05234 | protein_coding | | Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000005234 | gene5327 | | WN66_05243 | RFC3 | YNL290W~RFC3~Verified | WN66_05243 | protein_coding | | Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000005226 | gene5340 | | WN66_05256 | POP3 | YNL282W~POP3~Verified | WN66_05256 | protein_coding | | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000005225 | gene5341 | | WN66_05257 | HCH1 | YNL281W~HCH1~Verified | WN66_05257 | protein_coding | | Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004929 | gene5260 | | WN66_05176 | ELP6 | YMR312W~ELP6,HAP3,KTI4,TOT6~Verified | WN66_05176 | protein_coding | | Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004942 | gene5274 | | WN66_05190 | ERR3 | YMR323W~ERR3~Verified | WN66_05190 | protein_coding | | Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant in glucose | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000004944 | gene5276 | | WN66_05192 | PAU19 | YMR325W~PAU19~Verified | WN66_05192 | protein_coding | | Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000005280 | gene5282 | | WN66_05198 | COS1 | YNL336W~COS1~Verified | WN66_05198 | protein_coding | | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000005277 | gene5285 | | WN66_05201 | SNZ2 | YNL333W~SNZ2~Verified | WN66_05201 | protein_coding | | Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p | | | Gene | | | | | | | | | |

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[+]  | | SGD:S000005276 | gene5286 | | WN66_05202 | THI12 | YNL332W~THI12~Verified | WN66_05202 | protein_coding | | Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP | | | Gene | | | | | | | | | |

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